LEF1 Products
(Lymphoid Enhancer-Binding Factor 1 (LEF1))
Categories
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
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Featured LEF1 Categories
LEF1 Antibodies
High quality antibodies with extensive validation data.
LEF1 ELISA Kits
Reliable ELISA kits for a wide range of species.
LEF1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LEF1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
- (6)
- (1)
Cat. No.
ABIN5663810
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (3)
- (6)
Cat. No.
ABIN735248
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, RNAi
Validations
- (2)
- (6)
Cat. No.
ABIN565556
Quantity
100 μg
Datasheet
Datasheet
Recommended LEF1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6219167
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6219163
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6219160
Quantity
96 tests
Datasheet
Datasheet
Recommended LEF1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1309292
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123803
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309296
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our LEF1 products
: "38" in: , Vol. 1363, Issue Nucleic acids research, pp. 28-39, (1991): "A new cut&run low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/b-catenin tissue-specific genomic targets." in: Development (Cambridge, England), (2022) (PubMed).
: "Proteome Profile and Quantitative Proteomic Analysis of Buffalo (Bubalusbubalis) Follicular Fluid during Follicle Development." in: International journal of molecular sciences, Vol. 17, Issue 5, (2016) (PubMed).
: "Resveratrol Attenuates Hyperoxia-induced Oxidative Stress, Inflammation and Fibrosis and Suppresses Wnt/?-catenin Signaling in Lungs of Neonatal Rats." in: Clinical and experimental pharmacology & physiology, (2015) (PubMed).
: "MiR-27a regulates Wnt/beta-catenin signaling through targeting SFRP1 in glioma." in: Neuroreport, Vol. 26, Issue 12, pp. 695-702, (2015) (PubMed).
: "Methylprednisolone suppresses the Wnt signaling pathway in chronic lymphocytic leukemia cell line MEC-1 regulated by LEF-1 expression." in: International journal of clinical and experimental pathology, Vol. 8, Issue 7, pp. 7921-8, (2015) (PubMed).
: "The Regenerating Spinal Cord of Gecko Maintains Unaltered Expression of ?-Catenin Following Tail Amputation." in: Journal of molecular neuroscience : MN, (2014) (PubMed).
: "Identification of DNA-dependent protein kinase catalytic subunit as a novel interaction partner of lymphocyte enhancer factor 1." in: Medical molecular morphology, Vol. 46, Issue 1, pp. 14-9, (2013) (PubMed).
: "Regulation of ?-catenin nuclear dynamics by GSK-3? involves a LEF-1 positive feedback loop." in: Traffic (Copenhagen, Denmark), Vol. 12, Issue 8, pp. 983-99, (2011) (PubMed).
: "LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis." in: Blood, Vol. 116, Issue 16, pp. 2975-83, (2010) (PubMed).
Synonyms and alternative names related to LEF1
lymphoid enhancer binding factor 1 (LEF1), lymphoid enhancer binding factor 1 (lef1), lymphoid enhancer-binding factor 1 (lef1), lymphoid enhancer binding factor 1 (Lef1), lymphoid enhancer factor XLEF-1B (lef1), 3000002B05, AI451430, Lef-1, LEF-1, LEF1, TCF1ALPHA, TCF7L3, TCF10Protein level used designations for LEF1
- lymphoid enhancer binding factor-1
- lymphoid enhancer-binding factor 1
- lymphoid enhancer-binding factor 1-like
- etID310027.1
- LEF-1
- lymphoid enhancer binding factor 1 short isoform
- T cell-specific transcription factor 1-alpha
- TCF1-alpha
- lymphiod enhancer binding factor 1
- transcription factor LEF-1
- lymphoid enhancer binding factor 1
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