LECT1 Products
(Leukocyte Cell Derived Chemotaxin 1 (LECT1))
Categories
This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured LECT1 Categories
LECT1 Antibodies
High quality antibodies with extensive validation data.
LECT1 ELISA Kits
Reliable ELISA kits for a wide range of species.
LECT1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended LECT1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7435004
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN389196
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN524453
Quantity
100 μL
Datasheet
Datasheet
Recommended LECT1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957464
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957465
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1140560
Quantity
96 tests
Datasheet
Datasheet
Recommended LECT1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1309288
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130329
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7396529
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our LECT1 products
: "Chondromodulin-I derived from the inner meniscus prevents endothelial cell proliferation." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Vol. 31, Issue 4, pp. 538-43, (2013) (PubMed).: "Cell-specific epigenetic regulation of ChM-I gene expression: crosstalk between DNA methylation and histone acetylation." in: Biochemical and biophysical research communications, Vol. 365, Issue 1, pp. 124-30, (2007) (PubMed).
: "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis." in: Nature medicine, Vol. 12, Issue 10, pp. 1151-9, (2006) (PubMed).
: "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3." in: The Journal of biological chemistry, Vol. 279, Issue 27, pp. 28789-97, (2004) (PubMed).
: "Chondromodulin‑I suppresses tumorigenesis of human osteosarcoma cells." in: Molecular medicine reports, Vol. 16, Issue 6, pp. 8542-8548 (PubMed).
Synonyms and alternative names related to LECT1
chondromodulin L homeolog (cnmd.L), leukocyte cell derived chemotaxin 1 (lect1), chondromodulin (CNMD), chondromodulin (cnmd), chondromodulin (Cnmd), bricd3, BRICD3, Bricd3, Chm-1, chm-i, CHM-I, ChM-I, chm1, CHM1, chondromodulin-I, Lect1, MGC53801, MGC82444, MYETS1Protein level used designations for LECT1
- leukocyte cell derived chemotaxin 1
- chondromodulin-I
- chondromodulin-1-like
- chondromodulin-1
- leukocyte cell-derived chemotaxin 1
- BRICHOS domain containing 3
- chondromodulin I
- multiple myeloma tumor suppressor 1
- SCGP
- small cartilage-derived glycoprotein
- Chondromodulin 1
- chM-I
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