LATS2 Products
(LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
Categories
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
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Featured LATS2 Categories
LATS2 Antibodies
High quality antibodies with extensive validation data.
Recommended LATS2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
Cat. No.
ABIN753568
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC (p)
Validations
- (4)
- (2)
Cat. No.
ABIN1881491
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (3)
Cat. No.
ABIN7268192
Quantity
100 μL
Datasheet
Datasheet
Recommended LATS2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968209
Quantity
96 tests
Datasheet
Datasheet
Recommended LATS2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123724
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
Cat. No.
ABIN5508985
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093544
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our LATS2 products
: "The polarity protein Angiomotin p130 controls dendritic spine maturation." in: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
: "Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR ..." in: The Journal of biological chemistry, Vol. 291, Issue 34, pp. 17988-8005, (2016) (PubMed).
: "LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade." in: Oncogene, Vol. 34, Issue 1, pp. 73-83, (2015) (PubMed).
: "Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors." in: Molecular therapy. Nucleic acids, Vol. 4, pp. e246, (2015) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." in: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2." in: Nature cell biology, Vol. 16, Issue 10, pp. 962-71, 1-8, (2014) (PubMed).
: "The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl." in: Cell death and differentiation, Vol. 20, Issue 10, pp. 1330-40, (2013) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." in: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis." in: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34069-77, (2012) (PubMed).
Synonyms and alternative names related to LATS2
large tumor suppressor kinase 2 (LATS2), large tumor suppressor 2 (Lats2), large tumor suppressor kinase 2 (Lats2), large tumor suppressor kinase 2 (lats2), 4932411G09Rik, AV277261, AW228608, KPM, lats2Protein level used designations for LATS2
- kinase phosphorylated during mitosis protein
- large tumor suppressor homolog 2
- serine/threonine-protein kinase LATS2
- serine/threonine-protein kinase kpm
- large tumor suppressor, homolog 2
- LATS (large tumor suppressor, Drosophila) homolog 2
- LATS, large tumor suppressor, homolog 2
- serine/threonine kinase KPM
- warts-like kinase
- large tumor suppressor 2-like protein
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