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LASS5 Products

(LAG1 Homolog, Ceramide Synthase 5 (LASS5))

Categories

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl- (C16) ceramide) in a fumonisin B1-independent manner (By similarity).

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Featured LASS5 Categories

LASS5 Antibodies

High quality antibodies with extensive validation data.

LASS5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended LASS5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC, IF
Validations
  • (3)
Cat. No. ABIN7147471
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Application ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
Cat. No. ABIN709406
Quantity 100 μL
Datasheet Datasheet
Reactivity Horse, Human, Rabbit
Application WB
Validations
  • (1)
Cat. No. ABIN6742729
Quantity 100 μL
Datasheet Datasheet

Recommended LASS5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309179
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3103268
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3129163
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our LASS5 products

Zabielski, Blachnio-Zabielska, Lanza, Gopala, Manjunatha, Jakaitis, Persson, Gransee, Klaus, Schimke, Jensen, Nair: "Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice." in: American journal of physiology. Endocrinology and metabolism, Vol. 306, Issue 5, pp. E529-42, (2014) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells." in: Anticancer research, Vol. 32, Issue 3, pp. 753-60, (2012) (PubMed).

Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: "siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy." in: Anticancer research, Vol. 32, Issue 7, pp. 2479-85, (2012) (PubMed).

Kim, Qiao, Toop, Morris, Don: "A fluorescent assay for ceramide synthase activity." in: Journal of lipid research, Vol. 53, Issue 8, pp. 1701-7, (2012) (PubMed).

Yamane, Miyazawa, Moriya, Abe, Yamane et al.: "D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein ..." in: Biochimie, Vol. 93, Issue 9, pp. 1446-59, (2011) (PubMed).

Min, Mesika, Sivaguru, Van Veldhoven, Alexander, Futerman, Alexander: "(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1." in: Molecular cancer research : MCR, Vol. 5, Issue 8, pp. 801-12, (2007) (PubMed).

Spassieva, Seo, Jiang, Bielawski, Alvarez-Vasquez, Jazwinski, Hannun, Obeid: "Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 33931-8, (2006) (PubMed).

Lahiri, Futerman: "LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor." in: The Journal of biological chemistry, Vol. 280, Issue 40, pp. 33735-8, (2005) (PubMed).

Riebeling, Allegood, Wang, Merrill, Futerman: "Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors." in: The Journal of biological chemistry, Vol. 278, Issue 44, pp. 43452-9, (2003) (PubMed).

Synonyms and alternative names related to LASS5

ceramide synthase 5 (CERS5), ceramide synthase 5 (cers5), ceramide synthase 5 S homeolog (cers5.S), ceramide synthase 5 (Cers5), 2310081H14Rik, AU045339, AW544927, lass5, LASS5, Lass5, trh4, Trh4

Protein level used designations for LASS5

  • LAG1 homolog, ceramide synthase 5
  • LAG1 longevity assurance homolog 5-like
  • LAG1 longevity assurance homolog 5
  • TRAM homolog 4
  • longevity assurance homolog 5
  • translocating chain-associating membrane protein homolog 4
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