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KSR2 Products

(Kinase Suppressor of Ras 2 (KSR2))
Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

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Featured KSR2 Categories

KSR2 Antibodies

High quality antibodies with extensive validation data.

KSR2 ELISA Kits

Reliable ELISA kits for a wide range of species.

KSR2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KSR2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, RNAi
Validations
  • (2)
  • (5)
Cat. No. ABIN567007
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, WB, IF
Validations
  • (4)
Cat. No. ABIN567001
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (3)
Cat. No. ABIN655390
Quantity 400 μL
Datasheet Datasheet

Recommended KSR2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968126
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968125
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5648118
Quantity 96 tests
Datasheet Datasheet

Recommended KSR2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309084
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1309083
Quantity 25 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
Cat. No. ABIN5508983
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our KSR2 products

Pearce, Atanassova, Banton, Bottomley, van der Klaauw, Revelli, Hendricks, Keogh, Henning, Doree, Jeter-Jones, Garg, Bochukova, Bounds, Ashford, Gayton, Hindmarsh, Shield, Crowne, Barford, Wareham et al.: "KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation. ..." in: Cell, Vol. 155, Issue 4, pp. 765-77, (2013) (PubMed).

Fernandez, Henry, Lewis: "Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK." in: Molecular and cellular biology, Vol. 32, Issue 18, pp. 3718-31, (2012) (PubMed).

Jia, Souchelnytskyi: "Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast." in: Experimental oncology, Vol. 32, Issue 3, pp. 209-12, (2011) (PubMed).

Thompson, Andreeff, Studzinski, Vassilev: "1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53." in: Molecular cancer therapeutics, Vol. 9, Issue 5, pp. 1158-68, (2010) (PubMed).

Costanzo-Garvey, Pfluger, Dougherty, Stock, Boehm, Chaika, Fernandez, Fisher, Kortum, Hong, Jun, Ko, Schreiner, Volle, Treece, Swift, Winer, Chen, Wu, Leon, Shaw, McNeish, Kim, Morrison, Tschöp, Lewis: "KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity." in: Cell metabolism, Vol. 10, Issue 5, pp. 366-78, (2009) (PubMed).

Synonyms and alternative names related to KSR2

kinase suppressor of ras 2 (KSR2), kinase suppressor of ras 2 (Ksr2)

Protein level used designations for KSR2

  • kinase suppressor of Ras 2
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