KLRK1 Products
(Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))
Categories
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster. [provided by RefSeq, Dec 2010].
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Featured KLRK1 Categories
KLRK1 Antibodies
High quality antibodies with extensive validation data.
KLRK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
KLRK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KLRK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA
Validations
- (6)
Cat. No.
ABIN7193627
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, FACS, ELISA, IHC (fro), IF (cc), IF (p), IHC (p)
Validations
- (3)
- (4)
Cat. No.
ABIN730078
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS
Validations
- (7)
- (4)
Cat. No.
ABIN1027688
Quantity
100 tests
Datasheet
Datasheet
Recommended KLRK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4882179
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730443
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385461
Quantity
96 tests
Datasheet
Datasheet
Recommended KLRK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (6)
Cat. No.
ABIN7275337
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275342
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275334
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our KLRK1 products
: "Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis." in: RNA biology, Vol. 16, Issue 11, pp. 1592-1603, (2019) (PubMed).: "Quantitative and functional analysis of CD69(+) T regulatory lymphocytes in patients with periodontal disease." in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, (2016) (PubMed).
: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." in: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).
: "NK cell function is markedly impaired in patients with chronic lymphocytic leukaemia but is preserved in patients with small lymphocytic lymphoma." in: Oncotarget, Vol. 7, Issue 42, pp. 68513-68526, (2016) (PubMed).
: "A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease." in: Infection, Vol. 43, Issue 3, pp. 353-9, (2015) (PubMed).
: "Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain." in: BMC cancer, Vol. 15, pp. 1011, (2015) (PubMed).
: "Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human ..." in: PLoS pathogens, Vol. 11, Issue 3, pp. e1004671, (2015) (PubMed).
: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).
: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).
: "NKP30-B7-H6 Interaction Aggravates Hepatocyte Damage through Up-Regulation of Interleukin-32 Expression in Hepatitis B Virus-Related Acute-On-Chronic Liver Failure." in: PLoS ONE, Vol. 10, Issue 8, pp. e0134568, (2015) (PubMed).
Synonyms and alternative names related to KLRK1
killer cell lectin like receptor K1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (KLRK1), killer cell lectin-like receptor subfamily K, member 1 (Klrk1), killer cell lectin like receptor K1 (Klrk1), NKG2D protein (NKG2D), CD314, D6H12S2489E, D12S2489E, KLR, KLRK1, NKG2-D, NKG2D, Nkg2d, Nkrp2Protein level used designations for KLRK1
- killer cell lectin-like receptor subfamily K, member 1
- NKG2-D type II integral membrane protein-like
- NK cell receptor D
- NKG2-D type II integral membrane protein
- NKG2-D-activating NK receptor
- natural killer cell group 2D
- NK lectin-like receptor
- NKLLR
- NKR-P2, ortholog of human NKG2D
- killer cell lectin-like receptor subfamily K member 1
- NKG2-D activating NK receptor
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