KLRC1 Products
(Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1))
Categories
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured KLRC1 Categories
KLRC1 Antibodies
High quality antibodies with extensive validation data.
KLRC1 ELISA Kits
Reliable ELISA kits for a wide range of species.
KLRC1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KLRC1 Antibodies
Product
Reactivity
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Human
Application
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Cat. No.
ABIN652569
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
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Cat. No.
ABIN7161640
Quantity
100 μL
Datasheet
Datasheet
Reactivity
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Application
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Cat. No.
ABIN2856611
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100 μL
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Recommended KLRC1 ELISA Kits
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ABIN6730533
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730532
Quantity
96 tests
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HEK-293 Cells
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ABIN7275339
Quantity
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Cat. No.
ABIN7275338
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Source
HEK-293 Cells
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ABIN7275335
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Datasheet
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Latest Publications for our KLRC1 products
: "Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells." in: Scientific reports, Vol. 9, Issue 1, pp. 14916, (2019) (PubMed).: "The ANXA1 released from intestinal epithelial cells alleviate DSS-induced colitis by improving NKG2A expression of Natural Killer cells." in: Biochemical and biophysical research communications, Vol. 478, Issue 1, pp. 213-20, (2016) (PubMed).
: "Interferon Alpha Induces Sustained Changes in NK Cell Responsiveness to Hepatitis B Viral Load Suppression In Vivo." in: PLoS pathogens, Vol. 12, Issue 8, pp. e1005788, (2016) (PubMed).
: "IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 1, pp. 85-96, (2016) (PubMed).
: "CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients." in: Scientific reports, Vol. 6, pp. 25567, (2016) (PubMed).
: "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125544, (2015) (PubMed).
: "Overexpression of CD85j in TNBC patients inhibits Cetuximab-mediated NK-cell ADCC but can be restored with CD85j functional blockade." in: European journal of immunology, Vol. 45, Issue 5, pp. 1560-9, (2015) (PubMed).
: "WNT5A transforms intestinal CD8αα⁺ IELs into an unconventional phenotype with pro-inflammatory features." in: BMC gastroenterology, Vol. 15, pp. 173, (2015) (PubMed).
: "Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 5, pp. 2141-8, (2015) (PubMed).
: "Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 98, (2015) (PubMed).
Synonyms and alternative names related to KLRC1
killer cell lectin like receptor C1 (Klrc1), killer cell lectin like receptor C1 (KLRC1), NKG2-A/NKG2-B type II integral membrane protein-like (NKG2A), killer cell lectin-like receptor subfamily C, member 3 (KLRC3), killer cell lectin-like receptor subfamily C, member 1 (KLRC1), killer cell lectin-like receptor subfamily C, member 1 (Klrc1), CD159A, CD159a, KLRC1, NKG2, NKG2-A, NKG2A, NKG2B, rNKG2AProtein level used designations for KLRC1
- natural killer cell protein group 2-A (NKG2A)
- CD159 antigen-like family member A
- NK cell receptor A
- NKG2-A/B-activating NK receptor
- NKG2-A/NKG2-B type II integral membrane protein
- killer cell lectin-like receptor subfamily C, member 1
- C-lectin type II protein
- NKG2-1/B activating NK receptor
- NKG2-A/B type II integral membrane protein
- natural killer cell lectin
- natural killer group protein 2
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