KLHL12 Products
(Kelch-Like 12 (Drosophila) (KLHL12))
Categories
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).
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Featured KLHL12 Categories
KLHL12 Antibodies
High quality antibodies with extensive validation data.
KLHL12 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KLHL12 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7157267
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (2)
Cat. No.
ABIN1537222
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN969244
Quantity
100 μL
Datasheet
Datasheet
Recommended KLHL12 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229035
Quantity
96 tests
Datasheet
Datasheet
Recommended KLHL12 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308796
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123668
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093355
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KLHL12 products
: "COPII-coated membranes function as transport carriers of intracellular procollagen I." in: The Journal of cell biology, Vol. 216, Issue 6, pp. 1745-1759, (2017) (PubMed).: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).
: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).
Synonyms and alternative names related to KLHL12
Ski2 like RNA helicase (SKIV2L), kelch like family member 12 L homeolog (klhl12.L), kelch like family member 12 (KLHL12), kelch-like family member 12 (klhl12), kelch-like 12 (Klhl12), kelch-like family member 12 (Klhl12), C3ip1, C3IP1, DKIR, hDKIR, wu:fi60g03, zgc:92570Protein level used designations for KLHL12
- kelch-like 12 (Drosophila)
- kelch-like 12
- kelch-like protein 12
- fi60g03
- CUL3-interacting protein 1
- kelch-like protein C3IP1
- DKIR homolog
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