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KLHL12 Products

(Kelch-Like 12 (Drosophila) (KLHL12))

Categories

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (By similarity).

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Featured KLHL12 Categories

KLHL12 Antibodies

High quality antibodies with extensive validation data.

KLHL12 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KLHL12 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7157267
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (2)
Cat. No. ABIN1537222
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN969244
Quantity 100 μL
Datasheet Datasheet

Recommended KLHL12 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6229035
Quantity 96 tests
Datasheet Datasheet

Recommended KLHL12 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308796
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123668
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3093355
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our KLHL12 products

Gorur, Yuan, Kenny, Baba, Xu, Schekman: "COPII-coated membranes function as transport carriers of intracellular procollagen I." in: The Journal of cell biology, Vol. 216, Issue 6, pp. 1745-1759, (2017) (PubMed).

Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." in: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).

Jin, Pahuja, Wickliffe, Gorur, Baumgärtel, Schekman, Rape: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).

Synonyms and alternative names related to KLHL12

Ski2 like RNA helicase (SKIV2L), kelch like family member 12 L homeolog (klhl12.L), kelch like family member 12 (KLHL12), kelch-like family member 12 (klhl12), kelch-like 12 (Klhl12), kelch-like family member 12 (Klhl12), C3ip1, C3IP1, DKIR, hDKIR, wu:fi60g03, zgc:92570

Protein level used designations for KLHL12

  • kelch-like 12 (Drosophila)
  • kelch-like 12
  • kelch-like protein 12
  • fi60g03
  • CUL3-interacting protein 1
  • kelch-like protein C3IP1
  • DKIR homolog
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