HBcAb ELISA Kit

Catalog No. ABIN997017

Product Details HBcAb ELISA Kit

Target: HBcAb (Anti-Hepatitis B Virus Core Antibody (HBcAb))

Reactivity: Hepatitis B Virus (HBV)

Detection Method: Colorimetric

Method Type: Competition ELISA

Application: ELISA

Purpose: The HBcAb ELISA is an enzyme-linked immunosorbent assay for the qualitative identification of antibodies to hepatitis B antigen (HBcAg) in human serum/plasma.

Sample Type: Serum

Analytical Method: Qualitative

Specificity: 99%

Sensitivity: 99.92%

Application Details

Sample Volume: 50 μL

Assay Time: 1 - 2 h

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C

Expiry Date: 12-18 months

Target Details for HBcAb

Target: HBcAb (Anti-Hepatitis B Virus Core Antibody (HBcAb))

Alternative Name: HbcAb (HBcAb Products)

Target Type: Antibody, Antibody

Background: Hepatitis B virus (HBV) is an enveloped, double-stranded DNA virus belonging to the Hepadnaviridae family and is recognized as the major cause of blood transmitted hepatitis together with hepatitis C virus (HCV). Infection with HBV induces a spectrum of clinical manifestations ranging from mild, inapparent disease to fulminant hepatitis, severe chronic liver diseases, which in some cases can lead to cirrhosis and carcinoma of the liver. Classification of a hepatitis B infection requires the identification of a number of serological markers expressed during three phases (incubation, acute and convalescent) of the infection. Now several diagnostic tests are used for screening, clinical diagnosis and management of the disease. Hepatitis B “core ” antigen (HBcAg) is a major component of the viral structure.

HBcAg is composed of a single polypeptide of about 17 kD that is released upon disaggregation of the core particles, the antigen contains at least one immunological determinant. Antibodies to HBcAg (anti-HBc total antibody, and IgM) appear shortly after the appearance of HBsAg and persist for life both in persons who have recovered from a hepatitis B infection and in those who develop HBsAg-carrier status but in rare cases, a HBV infection can also run its course without the appearance of immunologically detectable anti-HBc (usually in immunosuppressed patients). Anti-HBc is a marker of acute, chronic or resolved HBV infection and screening for anti-HBc provides with information on the prevalence of the disease in different groups. In clinical diagnosis, the detection of anti-HBc is an important diagnostic marker and together with other hepatitis B test permits the diagnosis and management of the disease. In the absence of other hepatitis B markers(HBsAg-negative persons), anti-HBc may be the only indication of an existing hepatitis B viral infection.