Annexin V ELISA Kit

Catalog No. ABIN930753

Product Details Annexin V ELISA Kit

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Reactivity: Chemical

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Analytical Method: Quantitative

Characteristics: ELISA kit for the detection of Annexin V in the research laboratory
Alternative Names: Annexin V ELISA kit

Application Details

Application Notes: Optimal conditions to be determined by end-user

Plate: Pre-coated

Assay Procedure:

The Antiannexin V IgG/IgM is an indirect solid phase enzyme immunometric assay (ELISA). It is designed for the quantitative measurement of IgG or IgM class autoantibodies directed against annexin V. The microplate is coated with highly purified human recombinant annexin V. The microplate can be divided into 12 modules of 8 wells each or can be used completely for 96 determinations. Each well can be separated from the module (

Restrictions: For Research Use only

Handling

Storage: 4 °C

Storage Comment: Store at 2-8 °C.

Target Details for Annexin V

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Alternative Name: Annexin V (ANXA5 Products)

Target Type: Chemical

Background: Annexin V, also known as placental anticoagulant protein I (PAP I), not only belongs to a family of proteins that bind to phospholipids in a calcium dependent manner, but is also a potent vascular anticoagulant protein. Annexin V is necessary to maintain placental integrity and may have a thrombo-regulatory effect at the materno-fetal interface, as shown in a murine model. It has been suggested, that interference of anti-annexin V antibodies with the annexin V shield on the placental villi leads to the exposure of anionic procoagulant phospholipids. Anionic procoagulant phospholipids are known to enhance blood coagulation processes in the placental vasculature, and may be an important contributory factor of thrombosis and recurrent loss of pregnancy in the APS. Anti-annexin V antibodies are not only highly specific for APS, but also elevated levels of antibodies are detected in patients with systemic lupus diseases (SLE). It has been suggested that anti-annexin V autoantibodies may influence in the clinical course of rheumatoid arthritis. A significantly high frequency of arterial or venous thrombosis is found in patients with anti-annexin V antibodies. And are a significant risk factor for recurrent miscarriages in SLE patients.
Synonyms: Annexin V ELISA kit.

Pathways: Apoptosis