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CRLF2 ELISA Kit

CRLF2 Reactivity: Mouse AA 20-233 Colorimetric Sandwich ELISA 125 pg/mL - 8000 pg/mL Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
Catalog No. ABIN5692222
  • Target See all CRLF2 ELISA Kits
    CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
    Binding Specificity
    AA 20-233
    Reactivity
    • 5
    • 1
    Mouse
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Detection Range
    125 pg/mL - 8000 pg/mL
    Minimum Detection Limit
    125 pg/mL
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse CRLF2. 96wells/kit, with removable strips.
    Brand
    PicoKine™
    Sample Type
    Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO, Immunogen sequence: A20-L233
    Sensitivity
    < 10 pg/mL
    Components
    96-well plate precoated with antibody
    lyophilized recombinant standard
    biotinylated antibody (dilution 1:100)
    Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
    Sample diluent buffer
    Antibody diluent buffer
    ABC diluent buffer
    TMB color developing agent
    TMB stop solution
    Adhesive cover
    Top Product
    Discover our top product CRLF2 ELISA Kit
  • Assay Time
    15 min
    Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all CRLF2 ELISA Kits
    CRLF2 (Cytokine Receptor-Like Factor 2 (CRLF2))
    Alternative Name
    Crlf2 (CRLF2 Products)
    Synonyms
    CRLF2 ELISA Kit, CRL2 ELISA Kit, CRLF2Y ELISA Kit, TSLPR ELISA Kit, CRLM2 ELISA Kit, Ly114 ELISA Kit, Tpte2 ELISA Kit, Tslpr ELISA Kit, Crl2 ELISA Kit, cytokine receptor like factor 2 ELISA Kit, cytokine receptor-like factor 2 ELISA Kit, CRLF2 ELISA Kit, Crlf2 ELISA Kit
    Background

    Synonyms: Cytokine receptor-like factor 2, Cytokine receptor-like molecule 2, CRLM-2, Thymic stromal lymphopoietin protein receptor, TSLP receptor, Type I cytokine receptor delta 1, Crlf2, Crlm2, Tpte2, Tslpr

    Tissue Specificity: High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells.

    Background: Cytokine receptor-like factor 2, also known as TSLPR or CRL2, is a protein that in humans is encoded by the CRLF2 gene. It is mapped to Xp22.33. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin(TSLP). Together with the interleukin 7 receptor(IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene. In addition to it, it has been found that rearrangement of CRLF2 and JAK mutation together contribute to leukemogenesis in B-progenitor ALL.

    Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein.
    UniProt
    Q8CII9
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