ICOS ELISA Kit
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- Target See all ICOS ELISA Kits
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Binding Specificity
- AA 21-141
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Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Detection Range
- 62.5 pg/mL - 4000 pg/mL
- Minimum Detection Limit
- 62.5 pg/mL
- Application
- ELISA
- Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human ICOS. 96wells/kit, with removable strips.
- Brand
- PicoKine™
- Sample Type
- Cell Culture Supernatant, Plasma (EDTA - heparin), Serum
- Analytical Method
- Quantitative
- Specificity
- Expression system for standard: NSO, Immunogen sequence: E21-F141
- Sensitivity
- < 2 pg/mL
- Components
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96-well plate precoated with antibody
lyophilized recombinant standard
biotinylated antibody (dilution 1:100)
Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
Sample diluent buffer
Antibody diluent buffer
ABC diluent buffer
TMB color developing agent
TMB stop solution
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Inducible T-Cell Co-Stimulator (ICOS) ELISA Kit
ICOS Reactivity: Human Colorimetric Sandwich ELISA 0.15 ng/mL - 10 ng/mL Cell Culture Supernatant, Cell Lysate, Plasma, Serum, Tissue Homogenate
Inducible T-Cell Co-Stimulator (ICOS) ELISA KitICOS Reactivity: Rat Colorimetric Sandwich ELISA 78.125 pg/mL - 5000 pg/mL Plasma, Serum, Tissue Homogenate
Inducible T-Cell Co-Stimulator (ICOS) ELISA KitICOS Reactivity: Human Colorimetric Sandwich ELISA 1.2-300 ng/mL Cell Culture Supernatant, Plasma, Serum
Inducible T-Cell Co-Stimulator (ICOS) ELISA KitICOS Reactivity: Human Colorimetric Sandwich ELISA 15.625 pg/mL - 1000 pg/mL Cell Lysate, Plasma, Serum, Urine
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- Assay Time
- 15 min
- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Expiry Date
- 12 months
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- Target See all ICOS ELISA Kits
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- Alternative Name
- ICOS (ICOS Products)
- Background
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Synonyms: Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Tissue Specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
Background: Inducible T-cell costimulator is an immune checkpoint protein that in humans is encoded by the ICOS gene. The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation.
Cellular Localisation: Isoform 1: Cell membrane, Single-pass type I membrane protein. - UniProt
- Q9Y6W8
- Pathways
- Cancer Immune Checkpoints
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