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HYAL1 ELISA Kit

HYAL1 Reactivity: Human AA 22-435 Colorimetric Sandwich ELISA 15.6 pg/mL - 1000 pg/mL Cell Culture Supernatant, Cell Lysate, Plasma (EDTA - heparin), Serum
Catalog No. ABIN5692203
  • Target See all HYAL1 ELISA Kits
    HYAL1 (Hyaluronidase-1 (HYAL1))
    Binding Specificity
    AA 22-435
    Reactivity
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Detection Range
    15.6 pg/mL - 1000 pg/mL
    Minimum Detection Limit
    15.6 pg/mL
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Hyaluronidase1/HYAL1. 96wells/kit, with removable strips.
    Brand
    PicoKine™
    Sample Type
    Cell Culture Supernatant, Cell Lysate, Plasma (EDTA - heparin), Serum
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO, Immunogen sequence: F22-W435
    Sensitivity
    < 10 pg/mL
    Components
    96-well plate precoated with antibody
    lyophilized recombinant standard
    biotinylated antibody (dilution 1:100)
    Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
    Sample diluent buffer
    Antibody diluent buffer
    ABC diluent buffer
    TMB color developing agent
    TMB stop solution
    Adhesive cover
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  • Assay Time
    15 min
    Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all HYAL1 ELISA Kits
    HYAL1 (Hyaluronidase-1 (HYAL1))
    Alternative Name
    HYAL1 (HYAL1 Products)
    Synonyms
    HYAL-1 ELISA Kit, LUCA1 ELISA Kit, NAT6 ELISA Kit, Hya1 ELISA Kit, Hyal-1 ELISA Kit, hyaluronoglucosaminidase 1 ELISA Kit, HYAL1 ELISA Kit, Hyal1 ELISA Kit
    Background

    Synonyms: Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1

    Tissue Specificity: Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.

    Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic  pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.

    Cellular Localisation: Secreted
    UniProt
    Q12794
    Pathways
    Glycosaminoglycan Metabolic Process
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