HYAL1 ELISA Kit
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- Target See all HYAL1 ELISA Kits
- HYAL1 (Hyaluronidase-1 (HYAL1))
- Binding Specificity
- AA 22-435
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Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Detection Range
- 15.6 pg/mL - 1000 pg/mL
- Minimum Detection Limit
- 15.6 pg/mL
- Application
- ELISA
- Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Hyaluronidase1/HYAL1. 96wells/kit, with removable strips.
- Brand
- PicoKine™
- Sample Type
- Cell Culture Supernatant, Cell Lysate, Plasma (EDTA - heparin), Serum
- Analytical Method
- Quantitative
- Specificity
- Expression system for standard: NSO, Immunogen sequence: F22-W435
- Sensitivity
- < 10 pg/mL
- Components
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96-well plate precoated with antibody
lyophilized recombinant standard
biotinylated antibody (dilution 1:100)
Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
Sample diluent buffer
Antibody diluent buffer
ABC diluent buffer
TMB color developing agent
TMB stop solution
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- Assay Time
- 15 min
- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Expiry Date
- 12 months
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- Target See all HYAL1 ELISA Kits
- HYAL1 (Hyaluronidase-1 (HYAL1))
- Alternative Name
- HYAL1 (HYAL1 Products)
- Synonyms
- HYAL-1 ELISA Kit, LUCA1 ELISA Kit, NAT6 ELISA Kit, Hya1 ELISA Kit, Hyal-1 ELISA Kit, hyaluronoglucosaminidase 1 ELISA Kit, HYAL1 ELISA Kit, Hyal1 ELISA Kit
- Background
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Synonyms: Hyaluronidase-1, Hyal-1, Hyaluronoglucosaminidase-1, Lung carcinoma protein 1, LuCa-1, HYAL1, LUCA1
Tissue Specificity: Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
Background: Hyaluronidase-1, also known as HYAL1 or LUCA1, is an enzyme that in humans is encoded by the HYAL1 gene. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency.
Cellular Localisation: Secreted - UniProt
- Q12794
- Pathways
- Glycosaminoglycan Metabolic Process
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