IL1F9 ELISA Kit

Catalog No. ABIN5564184

Product Details IL1F9 ELISA Kit

Target: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Detection Range: 3.9-250 pg/mL

Minimum Detection Limit: 3.9 pg/mL

Application: ELISA

Sample Type: Cell Culture Supernatant, Serum

Analytical Method: Quantitative

Specificity: Detects natural and recombinant human IL-36gamma.

Cross-Reactivity: Human

Sensitivity: 3 pg/mL

Characteristics: IL-36gamma (human) ELISA Kit

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: +4°C
12 months after the day of manufacturing. See expiry date on ELISA Kit box.

Target Details for IL1F9

Target: IL1F9 (Interleukin 1 Family Member 9 (IL1F9))

Alternative Name: IL-36gamma (IL1F9 Products)

Synonyms: IL-1F9 ELISA Kit, IL-1H1 ELISA Kit, IL-1RP2 ELISA Kit, IL1E ELISA Kit, IL1F9 ELISA Kit, IL1H1 ELISA Kit, IL1RP2 ELISA Kit, Il36g ELISA Kit, Il1f9 ELISA Kit, RGD1563019 ELISA Kit, IL36G ELISA Kit, interleukin 36 gamma ELISA Kit, interleukin 1 family, member 9 ELISA Kit, interleukin 36, gamma ELISA Kit, interleukin-36 gamma ELISA Kit, IL36G ELISA Kit, Il1f9 ELISA Kit, Il36g ELISA Kit, LOC100065031 ELISA Kit

Background: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) are members of the IL-1 cytokine family that bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines occurs mainly in the lung and skin and can be derived from diverse epithelial cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of pro-inflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23, thus promoting neutrophil influx, dendritic cell (DC) activation, polarization of T helper type 1 (Th1) and IL-17-producing T cells (alphabeta T cells and gammadelta T cells) and keratinocyte proliferation. Induction of IL-36gamma in macrophages upon M. tuberculosis infection and its role in the release of antimicrobial peptides has been proposed. IL-36gamma is also induced in the lung in various models of asthma and can be produced by bronchial epithelial cells in response to viral infection, smoke or inflammatory cytokines and plays an important role in asthmatic pulmonary inflammation. IL-36gamma might be a potential biomarker of Inflammatory Bowel Disease and is highly expressed in inflamed skin from psoriasis patients and in Allergic Contact Dermatitis. IL-36gamma serum levels are enhanced and correlate to psoriasis severity and response to treatment with anti-TNF.