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Notch1 ELISA Kit

NOTCH1 Reactivity: Human AA 19-526 Colorimetric Sandwich ELISA
Catalog No. ABIN5510756
  • Target See all Notch1 (NOTCH1) ELISA Kits
    Notch1 (NOTCH1) (Notch 1 (NOTCH1))
    Binding Specificity
    AA 19-526
    Reactivity
    • 3
    • 3
    • 2
    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human NOTCH1
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO, Immunogen sequence: A19-Q526
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Characteristics

    Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

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  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all Notch1 (NOTCH1) ELISA Kits
    Notch1 (NOTCH1) (Notch 1 (NOTCH1))
    Alternative Name
    NOTCH1 (NOTCH1 Products)
    Synonyms
    notch1 ELISA Kit, NOTCH1 ELISA Kit, hn1 ELISA Kit, tan1 ELISA Kit, notch ELISA Kit, xotch ELISA Kit, xnotch ELISA Kit, notch-1 ELISA Kit, xnotch1 ELISA Kit, TAN1 ELISA Kit, hN1 ELISA Kit, 9930111A19Rik ELISA Kit, Mis6 ELISA Kit, N1 ELISA Kit, Tan1 ELISA Kit, lin-12 ELISA Kit, NOTCH ELISA Kit, Xotch ELISA Kit, notch1-a ELISA Kit, notch 1 ELISA Kit, fibropellin-1 ELISA Kit, Notch homolog 1, translocation-associated (Drosophila) ELISA Kit, Notch homolog 1, translocation-associated ELISA Kit, notch 1 S homeolog ELISA Kit, notch1 ELISA Kit, LOC100631526 ELISA Kit, NOTCH1 ELISA Kit, Notch1 ELISA Kit, notch1.S ELISA Kit
    Background

    Protein Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

    Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

    Synonyms: Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, NOTCH1, TAN1,

    Full Gene Name: notch 1

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein.
    UniProt
    P46531
    Pathways
    Notch Signaling, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
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