LGMN ELISA Kit

Catalog No. ABIN5510723

Product Details LGMN ELISA Kit

Target: LGMN (Legumain (LGMN))

Binding Specificity: AA 18-433

Reactivity: Human

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Legumain(total)

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: V18-Y433

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for LGMN

Target: LGMN (Legumain (LGMN))

Alternative Name: LGMN (LGMN Products)

Synonyms: AEP ELISA Kit, LGMN1 ELISA Kit, PRSC1 ELISA Kit, AI746452 ELISA Kit, AU022324 ELISA Kit, Prsc1 ELISA Kit, MGC64351 ELISA Kit, cb173 ELISA Kit, cb460 ELISA Kit, sb:cb173 ELISA Kit, zgc:76953 ELISA Kit, wu:fa98g05 ELISA Kit, wu:fj92g08 ELISA Kit, lgmn ELISA Kit, MGC88980 ELISA Kit, DELTA VACUOLAR PROCESSING ENZYME ELISA Kit, DELTAVPE ELISA Kit, delta vacuolar processing enzyme ELISA Kit, legumain ELISA Kit, legumain L homeolog ELISA Kit, delta vacuolar processing enzyme ELISA Kit, Legumain ELISA Kit, LGMN ELISA Kit, Lgmn ELISA Kit, lgmn.L ELISA Kit, lgmn ELISA Kit, DELTA-VPE ELISA Kit, MBOO_RS07785 ELISA Kit, Odosp_3582 ELISA Kit, LOC569153 ELISA Kit

Background:

Protein Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. .

Background: Legumain (asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme that in humans is encoded by the LGMN gene (previous symbolPRSC1). Using fluorescence in situ hybridization, the LGMN gene was mapped to chromosome 14q32.1. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types.

Synonyms: Legumain,3.4.22.34,Asparaginyl endopeptidase,Protease, cysteine 1,LGMN,PRSC1,

Full Gene Name: Legumain

Cellular Localisation: Lysosome.

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades