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FOLR2 ELISA Kit

FOLR2 Reactivity: Human AA 17-230 Colorimetric Sandwich ELISA
Catalog No. ABIN5510703
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    FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))
    Binding Specificity
    AA 17-230
    Reactivity
    • 4
    • 1
    Human
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human FOLR2
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: NSO, Immunogen sequence: T17-N230
    Cross-Reactivity (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Characteristics

    Tissue Specificity: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. .

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  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all FOLR2 ELISA Kits
    FOLR2 (Folate Receptor 2 (Fetal) (FOLR2))
    Alternative Name
    FOLR2 (FOLR2 Products)
    Synonyms
    FOLR2 ELISA Kit, BETA-HFR ELISA Kit, FBP ELISA Kit, FBP/PL-1 ELISA Kit, FR-BETA ELISA Kit, FR-P3 ELISA Kit, FBP2 ELISA Kit, Folbp-2 ELISA Kit, Folbp2 ELISA Kit, folate receptor 1 ELISA Kit, folate receptor beta ELISA Kit, folate receptor 2 (fetal) ELISA Kit, FOLR1 ELISA Kit, FOLR2 ELISA Kit, Folr2 ELISA Kit
    Background

    Protein Function: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH . Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. .

    Background: Folate receptor beta is a protein that in humans is encoded by the FOLR2 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68 % and 79 % sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.

    Synonyms: Folate receptor beta,FR-beta,Folate receptor 2,Folate receptor, fetal/placental,Placental folate-binding protein,FBP,FOLR2,

    Full Gene Name: Folate receptor beta

    Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor. Secreted.
    UniProt
    P14207
    Pathways
    Dicarboxylic Acid Transport
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