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- Target See all KREMEN1 ELISA Kits
- KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))
- Binding Specificity
- AA 20-395
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Reactivity
- Mouse
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Purpose
- Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Kremen-1
- Brand
- PicoKine™
- Analytical Method
- Quantitative
- Specificity
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Expression system for standard: NSO
Immunogen sequence: A20-G395 - Cross-Reactivity (Details)
- There is no detectable cross-reactivity with other relevant proteins.
- Characteristics
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Tissue Specificity: In the adult, widely expressed with high levels in heart, lung, kidney, skeletal muscle and testis. .
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- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
- Expiry Date
- 12 months
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- Target See all KREMEN1 ELISA Kits
- KREMEN1 (Kringle Containing Transmembrane Protein 1 (KREMEN1))
- Alternative Name
- Kremen1 (KREMEN1 Products)
- Background
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Protein Function: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling (By similarity). .
Background: Kremen protein 1 is a protein that in humans is encoded by the KREMEN1 gene. This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
Synonyms: Kremen protein 1,Dickkopf receptor,Kringle domain-containing transmembrane protein 1,Kringle-containing protein marking the eye and the nose,Kremen1,Kremen,
Full Gene Name: Kremen protein 1
Cellular Localisation: Membrane, Single-pass type I membrane protein. - UniProt
- Q99N43
- Pathways
- WNT Signaling
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