FcRn ELISA Kit

Catalog No. ABIN5510641

Product Details FcRn ELISA Kit

Target: FcRn (IgG receptor FcRn (FcRn))

Binding Specificity: AA 22-297

Reactivity: Mouse

Detection Method: Colorimetric

Method Type: Sandwich ELISA

Application: ELISA

Purpose: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse FCRN/FCGRT

Brand: PicoKine™

Analytical Method: Quantitative

Specificity: Expression system for standard: NSO
Immunogen sequence: S22-S297

Cross-Reactivity (Details): There is no detectable cross-reactivity with other relevant proteins.

Characteristics:

Tissue Specificity: Intestinal epithelium of suckling rodents. Expressed in neonatal intestine and fetal yolk sac.

Application Details

Plate: Pre-coated

Restrictions: For Research Use only

Handling

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Expiry Date: 12 months

Target Details for FcRn

Target: FcRn (IgG receptor FcRn (FcRn))

Alternative Name: Fcgrt (FcRn Products)

Synonyms: FCRN ELISA Kit, alpha-chain ELISA Kit, FcRn ELISA Kit, Fc fragment of IgG receptor and transporter ELISA Kit, Fc receptor, IgG, alpha chain transporter ELISA Kit, FCGRT ELISA Kit, Fcgrt ELISA Kit

Background:

Protein Function: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the selective uptake of IgG from milk and helps newborn animals to acquire passive immunity. IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids.

Background: The neonatal Fc receptor (FcRn), also known as the Brambell receptor, is a protein that in humans is encoded by the FCGRT gene. The neonatal Fc receptor is an Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. It was first discovered in rodents as a unique receptor capable of transporting IgG from mother's milk across the epithelium of newborn rodent's gut into the newborn's bloodstream. Further studies revealed a similar receptor in humans, leading to the naming as a neonatal Fc receptor. In humans, however, it is found in the placenta to help facilitate transport of mother's IgG to the growing fetus and it has also been shown to play a role in monitoring IgG turnover. Neonatal Fc receptor expression is up-regulated by the proinflammatory cytokine,TNF-i±, and down-regulated by IFN-i³.

Synonyms: IgG receptor FcRn large subunit p51,FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor,Fcgrt,Fcrn,

Full Gene Name: IgG receptor FcRn large subunit p51

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: Q61559

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process