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TGFA ELISA Kit

TGFA Reactivity: Rabbit AA 40-89 Colorimetric Sandwich ELISA
Catalog No. ABIN5510564
  • Target See all TGFA ELISA Kits
    TGFA (Transforming Growth Factor, alpha (TGFA))
    Binding Specificity
    AA 40-89
    Reactivity
    • 11
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Rabbit
    Detection Method
    Colorimetric
    Method Type
    Sandwich ELISA
    Application
    ELISA
    Purpose
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of rabbit TGF alpha
    Brand
    PicoKine™
    Analytical Method
    Quantitative
    Specificity
    Expression system for standard: E.coli,V40-A89
    Cross-Reactivity (Details)
    There is cross-reactivity with TGF beta 2, TGF beta 3, TGF beta 5<1 % .
    Characteristics

    Tissue Specificity: Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

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  • Plate
    Pre-coated
    Restrictions
    For Research Use only
  • Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Expiry Date
    12 months
  • Target See all TGFA ELISA Kits
    TGFA (Transforming Growth Factor, alpha (TGFA))
    Alternative Name
    TGFA (TGFA Products)
    Synonyms
    TFGA ELISA Kit, LOC100009482 ELISA Kit, TGF alpha ELISA Kit, TGFA ELISA Kit, wa-1 ELISA Kit, wa1 ELISA Kit, RATTGFAA ELISA Kit, TGFAA ELISA Kit, NV15606 ELISA Kit, si:ch211-10e8.7 ELISA Kit, transforming growth factor alpha ELISA Kit, transforming growth factor alpha L homeolog ELISA Kit, transforming growth factor-alpha ELISA Kit, transforming growth factor, alpha ELISA Kit, TGFA ELISA Kit, TGF-A ELISA Kit, Tgfa ELISA Kit, tgfa.L ELISA Kit, LOC100121300 ELISA Kit, LOC100009150 ELISA Kit, tgfa ELISA Kit
    Background

    Protein Function: TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

    Background: Transforming growth factor alpha(TGF-alpha) is upregulated in some rabbit cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects. TGFalpha stimulates neural cell proliferation in the adult injured brain. Transforming growth factor alpha gene(TGFA) maps to rabbit chromosome 2 close to the breakpoint of the t(2,8) variant translocation in Burkitt lymphoma. Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells, the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic rabbit TGF-alpha showed similar immunoreactivity when compared with rabbit TGF-alpha. Thus, the 50-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines.

    Synonyms: Protransforming growth factor alpha,Transforming growth factor alpha,TGF-alpha,EGF-like TGF,ETGF,TGF type 1,TGFA,

    Full Gene Name: Protransforming growth factor alpha

    Cellular Localisation: Transforming growth factor alpha: Secreted, extracellular space.
    UniProt
    P01135
    Pathways
    NF-kappaB Signaling, RTK Signaling, EGFR Signaling Pathway
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