beta Catenin ELISA Kit
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- Target See all beta Catenin (CATNB) ELISA Kits
- beta Catenin (CATNB) (Catenin, beta (CATNB))
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Reactivity
- Human
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Application
- ELISA
- Sample Type
- Cell Lysate
- Cross-Reactivity (Details)
- Calculated cross reactivity: Hu
- Characteristics
- Catenin, beta, Human, ELISA Kit
- Components
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- 1. Microtiter Plate, Catenin antibody-coated microtiter, 1x96 wells.
- 2. Beta-Catenin Detection Ab, 1x11ml
- 3. IgG (HRP) Ab, 1x11ml
- 4. TMB Substrate, 1x 11ml
- 5. STOP Solution, 1x11ml
- 6. Wash Buffer (20X), 1x25ml
- 7. Sample Diluent, 1x25ml.
- 8. Cell Lysis Buffer, 1x15ml
- Top Product
- Discover our top product CATNB ELISA Kit
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Catenin, beta (CATNB) ELISA Kit
CATNB Reactivity: Rat Colorimetric Sandwich ELISA 0.156 ng/mL - 10 ng/mL Plasma, Serum, Tissue Homogenate
Catenin, beta (CATNB) ELISA KitCATNB Reactivity: Human Colorimetric Sandwich ELISA 312-20000 pg/mL Cell Culture Supernatant, Plasma, Serum, Tissue Homogenate
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- Restrictions
- For Research Use only
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- Storage
- -20 °C
- Storage Comment
- -20°C
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- Target See all beta Catenin (CATNB) ELISA Kits
- beta Catenin (CATNB) (Catenin, beta (CATNB))
- Alternative Name
- Catenin, beta (CATNB Products)
- Background
- A key downstream effector in the Wnt signaling pathway is b-catenin (1). It is implicated in two major biological processes of vertebrates: early embryonic development (2) and tumorigenesis (3). Casein kinase 1 phosphorylates b-catenin on Ser45. This phosphorylation event primes b-catenin for subsequent phosphorylation by GSK-3 (4-6). GSK-3b destabilizes b-catenin by phosphorylating it at Ser33, 37 and Thr41 (7). Mutations in these phosphorylation sites which result in the stabilization of b-catenin protein levels have been found in many tumor cell lines (8).
- Pathways
- Peptide Hormone Metabolism
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