CXCL2 ELISA Kit
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- Target See all CXCL2 ELISA Kits
- CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))
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Reactivity
- Mouse
- Detection Method
- Colorimetric
- Method Type
- Sandwich ELISA
- Detection Range
- 0.02-1.0 ng/mL
- Minimum Detection Limit
- 0.02 ng/mL
- Application
- ELISA
- Sample Type
- Cell Culture Supernatant, Serum, Plasma (heparin), Plasma (citrate), Plasma (EDTA)
- Analytical Method
- Quantitative
- Specificity
- Natural and recombinant Mouse MIP-2 Ligand
- Sensitivity
- 7 pg/mL
- Material not included
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- Microplate reader.
- Pipettes and pipette tips.
- EP tube Deionized or distilled water.
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- Discover our best selling CXCL2 ELISA Kit
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- Discover our top product CXCL2 ELISA Kit
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- Application Notes
- Detection Wavelength: 450 nm
- Sample Volume
- 20 μL
- Assay Time
- 3 h
- Plate
- Pre-coated
- Restrictions
- For Research Use only
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- Storage
- 4 °C
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- Target See all CXCL2 ELISA Kits
- CXCL2 (Chemokine (C-X-C Motif) Ligand 2 (CXCL2))
- Alternative Name
- MIP-2 (CXCL2 Products)
- Synonyms
- CINC-2a ELISA Kit, GRO2 ELISA Kit, GROb ELISA Kit, MGSA-b ELISA Kit, MIP-2a ELISA Kit, MIP2 ELISA Kit, MIP2A ELISA Kit, SCYB2 ELISA Kit, GRO3 ELISA Kit, Gro2 ELISA Kit, MIP-2 ELISA Kit, Mgsa-b ELISA Kit, Mip2 ELISA Kit, Scyb ELISA Kit, Scyb2 ELISA Kit, Mip-2 ELISA Kit, GROB ELISA Kit, MIP-2alpha ELISA Kit, C-X-C motif chemokine ligand 2 ELISA Kit, chemokine (C-X-C motif) ligand 2 ELISA Kit, CXCL2 ELISA Kit, Cxcl2 ELISA Kit
- Background
- Mouse macrophage inflammatory protein-2 (MIP-2), also known as CXCL2, was originally identified as a heparin-binding protein secreted by an LPS-stimulated mouse macrophage cell line (1). A cDNA clone encoding the protein was isolated from this cell line and characterized (2). Based on its protein and DNA sequences, mouse MIP-2 was classified as a member of the alpha (CXC) chemokine family of inflammatory and immunoregulatory cytokines (3).Mouse MIP-2 cDNA encodes a 100 amino acid residue precursor protein from which the amino-terminal 27 amino acid residues are cleaved to generate the mature mouse MIP-2. The protein sequence of mouse MIP-2 shows approximately 63 % identity to that of mouse KC, another mouse alpha chemokine. Mouse MIP-2 is also 60 % identical to human GROβ and GROγ(2). Based on these protein sequence similarities, it is likely that mouse KC and MIP-2 are homologs of human GROα, β and γ chemokines. Since chemokines with protein sequence homology to human IL-8 have not been identified in mice, it has been suggested that the mouse KC and MIP-2 are functional homologs of human IL-8 in mice (3, 4). A putative mouse homolog of the human IL-8 receptor beta (IL-8 Rβ) has also been cloned. This receptor shows 71 % identity to human IL-8 Rβ and 68 % identity to human IL-8 Rα. Both mouse KC and MIP-2 bind mouse IL-8 Rβ with high affinity (5).Like human IL-8, mouse MIP-2 exhibits potent neutrophil chemotactic activity and may be a key mediator of neutrophil recruitment in response to tissue injury and infection (3, 4). Increased MIP-2 expression has been found to be associated with neutrophil influx in various inflammatory conditions (6 - 10).
- Pathways
- Cellular Response to Molecule of Bacterial Origin
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