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SensoLyte® 440 Cathepsin B Assay Kit

FRET Fluorometric
Catalog No. ABIN1882437
  • Target See all Cathepsin B (CTSB) Kits
    Cathepsin B (CTSB)
    Detection Method
    Fluorometric
    Application
    Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Brand
    SensoLyte®
    Characteristics
    The SensoLyte® 440 Cathepsin B Assay Kit provides a fluorogenic peptide for measurement of enzyme activity. This peptide releases the AMC (7-amino-4-methylcoumarin) fluorophore upon cathepsin B cleavage and can be detected with excitation at 354 nm and emission at 442 nm.
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  • Comment

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Handling Advice
    Protect Components A and B from light and moisture.
    Storage
    -80 °C
    Storage Comment
    Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Component D can be stored at room temperature for convenience
  • Vidal, Aguiar, Phansalkar, McAlpine, Napolitano, Chen, Araújo, Pauli, Bedran-Russo: "Galloyl moieties enhance the dentin biomodification potential of plant-derived catechins." in: Acta biomaterialia, Vol. 10, Issue 7, pp. 3288-94, (2014) (PubMed).

  • Target
    Cathepsin B (CTSB)
    Alternative Name
    Cathepsin B (CTSB Products)
    Synonyms
    APPS Kit, CPSB Kit, CB Kit, apps Kit, cpsb Kit, LOC692390 Kit, CTSB Kit, cathepsin B Kit, cathepsin B S homeolog Kit, CTSB Kit, Ctsb Kit, ctsb.S Kit, LOC692390 Kit
    Background
    Cathepsins are a class of globular lysosomal proteases playing a vital role in mammalian cellular turnover. They degrade polypeptides and are distinguished by their substrate specificities. The cathepsin family consists of 12 cysteine proteases with broad exo- and endopeptidase activity, of which Cathepsin B is a member. Elevated levels of cathepsin B were detected in metastases and neurological disorders including Alzheimer's disease (AD).
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