KIR3DL3 Products
(Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 3 (KIR3DL3))
Categories
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes.
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Featured KIR3DL3 Categories
KIR3DL3 Antibodies
High quality antibodies with extensive validation data.
Recommended KIR3DL3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN7255129
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN653117
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7157532
Quantity
100 μL
Datasheet
Datasheet
Recommended KIR3DL3 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275103
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275104
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Mammalian Cells
Validations
- (1)
Cat. No.
ABIN7538348
Quantity
50 μg
Datasheet
Datasheet
Synonyms and alternative names related to KIR3DL3
killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 3 (KIR3DL3), CD158Z, KIR3DL7, KIR44, KIRC1Protein level used designations for KIR3DL3
- CD158 antigen-like family member Z
- killer cell Ig-like receptor KIR3DL7
- killer cell immunoglobulin-like receptor 3DL3
- killer cell inhibitory receptor 1
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