KIR3DL1 Products
(Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
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Featured KIR3DL1 Categories
KIR3DL1 Antibodies
High quality antibodies with extensive validation data.
KIR3DL1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended KIR3DL1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (5)
Cat. No.
ABIN5611325
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
Cat. No.
ABIN7157524
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (4)
Cat. No.
ABIN5611327
Quantity
100 μL
Datasheet
Datasheet
Recommended KIR3DL1 ELISA Kits
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Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957298
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4883509
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6385893
Quantity
96 tests
Datasheet
Datasheet
Recommended KIR3DL1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123687
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308699
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7394318
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our KIR3DL1 products
: "Clinical impact of NK-cell reconstitution after reduced intensity conditioned unrelated cord blood transplantation in patients with acute myeloid leukemia: analysis of a prospective phase II ..." in: Bone marrow transplantation, Vol. 52, Issue 10, pp. 1428-1435, (2017) (PubMed).: "Immunoelectron microscopic observation of the subcellular localization of kisspeptin, neurokinin B and dynorphin A in KNDy neurons in the arcuate nucleus of the female rat." in: Neuroscience letters, Vol. 612, pp. 161-6, (2016) (PubMed).
: "The Incubation Period of Primary Epstein-Barr Virus Infection: Viral Dynamics and Immunologic Events." in: PLoS pathogens, Vol. 11, Issue 12, pp. e1005286, (2015) (PubMed).
: "Neurokinin B- and kisspeptin-positive fibers as well as tuberoinfundibular dopaminergic neurons directly innervate periventricular hypophyseal dopaminergic neurons in rats and mice." in: Neuroscience research, Vol. 84, pp. 10-8, (2014) (PubMed).
: "Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 192, Issue 1, pp. 503-11, (2013) (PubMed).
: "CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients." in: European journal of immunology, Vol. 42, Issue 2, pp. 447-57, (2012) (PubMed).
: "Membrane-bound IL-21 promotes sustained ex vivo proliferation of human natural killer cells." in: PLoS ONE, Vol. 7, Issue 1, pp. e30264, (2012) (PubMed).
: "NKp46 identifies an NKT cell subset susceptible to leukemic transformation in mouse and human." in: The Journal of clinical investigation, Vol. 121, Issue 4, pp. 1456-70, (2011) (PubMed).
: "Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 1, pp. 62-72, (2010) (PubMed).
: "NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs." in: PLoS ONE, Vol. 5, Issue 8, pp. e11966, (2010) (PubMed).
Synonyms and alternative names related to KIR3DL1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (KIR3DL1), uncharacterized LOC100437736 (LOC100437736), killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 (KIR3DL1), killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 (Kir3dl1), CD158E1, KIR, KIR3DL1, KIR3DL1/S1, KIR3DL3, Kirl1, Kirl2, Krl1, NKAT3, NKB1, NKB1BProtein level used designations for KIR3DL1
- killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
- killer immunoglobulin-like receptor KIR3DL-like 1
- killer cell immunoglobulin-like receptor variant 001
- killer cell immunoglobulin-like receptor KIR3DL1-like 1
- killer cell immunoglobulin-like receptor 3DL1-like
- CD158 antigen-like family member E
- HLA-BW4-specific inhibitory NK cell receptor
- KIR antigen 3DL1
- MHC class I NK cell receptor
- NK-receptor
- NKAT-3
- killer Ig receptor
- killer cell immunoglobulin-like receptor 3DL1
- natural killer-associated transcript 3
- p70 NK receptor CL-2/CL-11
- p70 killer cell inhibitory receptor
- p70 natural killer cell receptor clones CL-2/CL-11
- KIR-like receptor 1
- killer cell immunoglobulin-like receptor Kir3dl1
- killer immunoglobulin receptor-like protein 1
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