KIR2DS4 Products
(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 (KIR2DS4))
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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].
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Featured KIR2DS4 Categories
KIR2DS4 Antibodies
High quality antibodies with extensive validation data.
KIR2DS4 ELISA Kits
Reliable ELISA kits for a wide range of species.
KIR2DS4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KIR2DS4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7157519
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN1499052
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC
Validations
- (3)
Cat. No.
ABIN1859540
Quantity
100 μL
Datasheet
Datasheet
Recommended KIR2DS4 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957300
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5656218
Quantity
96 tests
Datasheet
Datasheet
Recommended KIR2DS4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN934899
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7403051
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our KIR2DS4 products
: "Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 116, Issue 26, pp. 12964-12973, (2019) (PubMed).: "Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 11, pp. 4292-4300, (2017) (PubMed).
: "2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells." in: Genes and immunity, Vol. 16, Issue 5, pp. 301-10, (2015) (PubMed).
: "Detection and significance of cytotoxic cell subsets in biopsies of HCV-infected human livers." in: Archivum immunologiae et therapiae experimentalis, Vol. 62, Issue 2, pp. 153-60, (2014) (PubMed).
: "CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients." in: European journal of immunology, Vol. 42, Issue 2, pp. 447-57, (2012) (PubMed).
: "NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs." in: PLoS ONE, Vol. 5, Issue 8, pp. e11966, (2010) (PubMed).
Synonyms and alternative names related to KIR2DS4
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 4 (KIR2DS4), CD158I, KIR1D, KIR412, KKA3, NKAT8Protein level used designations for KIR2DS4
- CD158 antigen-like family member I
- KIR antigen 2DS4
- MHC class I NK cell receptor
- NKAT-8
- P58 natural killer cell receptor clones CL-39/CL-17
- killer cell immunoglobulin-like receptor 2DS4
- killer inhibitory receptor 4-1-2
- natural killer cell inhibitory receptor
- natural killer-associated transcript 8
- p58 NK receptor CL-39/CL-17
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