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KIR2DS3 Proteins

(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 3 (KIR2DS3))

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].

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KIR2DS3 Protein (Myc-DYKDDDDK Tag) (ABIN2724259)

KIR2DS3 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD

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Popular KIR2DS3 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

KIR2DS3 Protein (Myc-DYKDDDDK Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2724259

Quantity 20 μg

Datasheet Datasheet

Aliases for KIR2DS3 Proteins

killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3 (KIR2DS3) Proteins
NKAT7 Proteins

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