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KIR2DL5A Products

(Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 5A (KIR2DL5A))

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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008].

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Featured KIR2DL5A Categories

KIR2DL5A Antibodies

High quality antibodies with extensive validation data.

KIR2DL5A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended KIR2DL5A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application FACS, ICC
Validations
  • (1)
  • (3)
Cat. No. ABIN2749214
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7189489
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7245485
Quantity 200 μL
Datasheet Datasheet

Recommended KIR2DL5A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275090
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN7275091
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7505603
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our KIR2DL5A products

Estefanía, Flores, Gómez-Lozano, Aguilar, López-Botet, Vilches: "Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4402-10, (2007) (PubMed).

Synonyms and alternative names related to KIR2DL5A

killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 5A (KIR2DL5A), CD158F, KIR2DL5, KIR2DL5.1, KIR2DL5.3, KIR2DL5B

Protein level used designations for KIR2DL5A

  • killer cell immunoglobulin-like receptor 2DL5A
  • killer cell immunoglobulin-like receptor KIR2DL5A
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5
  • killer-cell Ig-like receptor
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