KDM2A Products
(Lysine (K)-Specific Demethylase 2A (KDM2A))
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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
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Featured KDM2A Categories
KDM2A Antibodies
High quality antibodies with extensive validation data.
KDM2A Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KDM2A Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN387896
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
- (3)
Cat. No.
ABIN7193407
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7244933
Quantity
200 μL
Datasheet
Datasheet
Recommended KDM2A ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228355
Quantity
96 tests
Datasheet
Datasheet
Recommended KDM2A Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123806
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353718
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093402
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KDM2A products
: "HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway." in: Journal of cellular physiology, (2018) (PubMed).: "Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells." in: The Journal of biological chemistry, Vol. 289, Issue 11, pp. 7483-96, (2014) (PubMed).
: "KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling." in: The Journal of clinical investigation, Vol. 123, Issue 12, pp. 5231-46, (2013) (PubMed).
: "Histone demethylation by a family of JmjC domain-containing proteins." in: Nature, Vol. 439, Issue 7078, pp. 811-6, (2006) (PubMed).
: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, (2005) (PubMed).
: "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 6, Issue 1, pp. 63-70, (1999) (PubMed).
Synonyms and alternative names related to KDM2A
lysine demethylase 2A (KDM2A), lysine (K)-specific demethylase 2A (Kdm2a), lysine demethylase 2A (Kdm2a), lysine (K)-specific demethylase 2Aa (kdm2aa), 5530401A10Rik, 100043628, AA589516, AW536790, Cxxc8, CXXC8, fb76b11, Fbl7, FBL7, Fbl11, FBL11, FBXL11, Fbxl11, Gm4560, Jhdm1, JHDM1A, Jhdm1a, KDM2A, lalina, LILINA, wu:fb76b11, wu:fj11c04, zgc:158441, zgc:158606Protein level used designations for KDM2A
- F-box and leucine-rich repeat protein 11
- jumonji C domain-containing histone demethylase 1A
- lysine-specific demethylase 2A
- F-box protein containing leucine repeats
- F-box/LRR-repeat protein 11
- [Histone-H3]-lysine-36 demethylase 1A
- jmjC domain-containing histone demethylation protein 1A
- lysine (K)-specific demethylase 2A
- CXXC-type zinc finger protein 8
- JmjC domain-containing histone demethylation protein 1B
- lysine (K)-specific demethylase 2B
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