KCNQ2 Products
(Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 2 (KCNQ2))
Categories
The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured KCNQ2 Categories
KCNQ2 Antibodies
High quality antibodies with extensive validation data.
KCNQ2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KCNQ2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (2)
- (3)
Cat. No.
ABIN2776304
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (4)
Cat. No.
ABIN2776303
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Bat, Chicken, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (2)
Cat. No.
ABIN202417
Quantity
100 μL
Datasheet
Datasheet
Recommended KCNQ2 Proteins
Product
Reactivity
Source
Validations
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Quantity
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Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308479
Quantity
2 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3110096
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137656
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCNQ2 products
: "Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 9, pp. 3782-93, (2015) (PubMed).: "Epilepsy-causing mutations in Kv7.2 C-terminus affect binding and functional modulation by calmodulin." in: Biochimica et biophysica acta, Vol. 1852, Issue 9, pp. 1856-66, (2015) (PubMed).
: "K(V)7.4 channels participate in the control of rodent renal vascular resting tone." in: Acta physiologica (Oxford, England), Vol. 214, Issue 3, pp. 402-14, (2015) (PubMed).
: "Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A." in: Human mutation, Vol. 35, Issue 3, pp. 356-67, (2014) (PubMed).
: "Polarized axonal surface expression of neuronal KCNQ potassium channels is regulated by calmodulin interaction with KCNQ2 subunit." in: PLoS ONE, Vol. 9, Issue 7, pp. e103655, (2014) (PubMed).
: "Membrane microdomain determines the specificity of receptor-mediated modulation of Kv7/M potassium currents." in: Neuroscience, Vol. 254, pp. 70-9, (2013) (PubMed).
: "Kv7/M-type potassium channels in rat skin keratinocytes." in: Pflügers Archiv : European journal of physiology, Vol. 465, Issue 9, pp. 1371-81, (2013) (PubMed).
: "Functional effects of KCNQ K(+) channels in airway smooth muscle." in: Frontiers in physiology, Vol. 4, pp. 277, (2013) (PubMed).
: "Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons." in: PLoS ONE, Vol. 7, Issue 10, pp. e48557, (2012) (PubMed).
: "Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 48, pp. 17637-48, (2011) (PubMed).
Synonyms and alternative names related to KCNQ2
potassium voltage-gated channel subfamily Q member 2 (KCNQ2), potassium voltage-gated channel, subfamily Q, member 2 (Kcnq2), potassium voltage-gated channel subfamily Q member 2 (Kcnq2), potassium voltage-gated channel subfamily KQT member 2 (LOC100537363), potassium voltage-gated channel, KQT-like subfamily, member 2a (kcnq2a), BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KQT2, KV7.2, KVEBN1, mKQT2.3, mKQT2.4, Nmf134, zgc:171872Protein level used designations for KCNQ2
- KQT-like 2
- neuroblastoma-specific potassium channel protein
- neuroblastoma-specific potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel subfamily KQT member 2
- voltage-gated potassium channel subunit Kv7.2
- potassium channel subunit alpha KvLQT2
- potassium voltage-gated channel, subfamily Q, member 2
- potassium voltage-gated channel KQT-like subfamily member 2.3
- potassium voltage-gated channel KQT-like subfamily member 2.4
- potassium voltage-gated channel, KQT-like subfamily, member 2
- LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 2
- uncharacterized protein LOC100141342
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