KCNA1 Products
(Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 1 (KCNA1))
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This gene encodes a voltage-gated delayed potassium channel that is phylogenetically related to the Drosophila Shaker channel. The encoded protein has six putative transmembrane segments (S1-S6), and the loop between S5 and S6 forms the pore and contains the conserved selectivity filter motif (GYGD). The functional channel is a homotetramer. The N-terminus of the channel is associated with beta subunits that can modify the inactivation properties of the channel as well as affect expression levels. The C-terminus of the channel is complexed to a PDZ domain protein that is responsible for channel targeting. Mutations in this gene have been associated with myokymia with periodic ataxia (AEMK). [provided by RefSeq, Jul 2008].
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Featured KCNA1 Categories
KCNA1 Antibodies
High quality antibodies with extensive validation data.
KCNA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KCNA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7163948
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7242236
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
Cat. No.
ABIN517306
Quantity
100 μg
Datasheet
Datasheet
Recommended KCNA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308386
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308384
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3114469
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCNA1 products
: "N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity." in: Molecular brain, Vol. 8, pp. 4, (2015) (PubMed).: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." in: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).
: "The Polarity Protein Pals1 Regulates Radial Sorting of Axons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 29, pp. 10474-84, (2015) (PubMed).
: "Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation." in: Basic research in cardiology, Vol. 110, Issue 5, pp. 505, (2015) (PubMed).
: "Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis." in: Neurobiology of disease, Vol. 73, pp. 96-105, (2014) (PubMed).
: "Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia." in: PLoS ONE, Vol. 9, Issue 10, pp. e109303, (2014) (PubMed).
: "Control and plasticity of the presynaptic action potential waveform at small CNS nerve terminals." in: Neuron, Vol. 84, Issue 4, pp. 778-89, (2014) (PubMed).
: "Auditory nerve perinodal dysmyelination in noise-induced hearing loss." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 7, pp. 2684-8, (2014) (PubMed).
: "Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells." in: The European journal of neuroscience, Vol. 39, Issue 11, pp. 1771-83, (2014) (PubMed).
: "Kv7.2 regulates the function of peripheral sensory neurons." in: The Journal of comparative neurology, Vol. 522, Issue 14, pp. 3262-80, (2014) (PubMed).
Synonyms and alternative names related to KCNA1
potassium voltage-gated channel subfamily A member 1 (KCNA1), potassium voltage-gated channel, shaker-related subfamily, member 1 (KCNA1), potassium voltage-gated channel, shaker-related subfamily, member 1 (Kcna1), potassium voltage-gated channel subfamily A member 1 (Kcna1), fragile site, aphidicolin type, common, fra(12)(q24) (FRA12E), AEMK, AI840627, EA1, HBK1, HUK1, Kca1-1, Kcna, KCNA1, Kcpvd, KV1.1, Kv1.1, MBK1, mceph, Mk-1, MK1, RBK1, ShakProtein level used designations for KCNA1
- potassium voltage-gated channel subfamily A member 1
- voltage-gated K(+) channel HuKI
- voltage-gated potassium channel HBK1
- voltage-gated potassium channel subunit Kv1.1
- potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)
- voltage-gated potassium channel Kv1.1
- potassium voltage-gated channel, shaker-related subfamily, member 1
- voltage-gated potassium channel
- potassium voltage-gated channel subfamily A member 1-like
- MKI
- brain potassium channel protein-1
- megencephaly
- potassium voltage gated channel, shaker related subfamily, member 1
- IA
- RBKI
- RCK1
- potassium (K+) channel protein voltage dependent
- potassium voltage gated channel shaker related subfamily member 1
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