KCC2 Products
(Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5))
Categories
K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008].
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Featured KCC2 Categories
KCC2 Antibodies
High quality antibodies with extensive validation data.
KCC2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended KCC2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, IF, ICC
Validations
- (4)
Cat. No.
ABIN1027708
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN652057
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Mouse, Rat
Application
IHC, IF
Validations
- (3)
Cat. No.
ABIN7075650
Quantity
100 μL
Datasheet
Datasheet
Recommended KCC2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6210805
Quantity
96 tests
Datasheet
Datasheet
Recommended KCC2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3118086
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3136773
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our KCC2 products
: "The adipocyte hormone leptin sets the emergence of hippocampal inhibition in mice." in: eLife, Vol. 7, (2019) (PubMed).: "Calpain-2 as a Treatment Target in Prenatal Stress-induced Epileptic Spasms in Infant Rats." in: Experimental neurobiology, Vol. 28, Issue 4, pp. 529-536, (2019) (PubMed).
: "Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain." in: Experimental neurology, Vol. 306, pp. 105-116, (2019) (PubMed).
: "Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition." in: eLife, Vol. 6, (2018) (PubMed).
: "Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures. ..." in: Nature communications, Vol. 6, pp. 8038, (2015) (PubMed).
: "Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures." in: Frontiers in cellular neuroscience, Vol. 9, pp. 368, (2015) (PubMed).
: "Down-regulation of KCC2 expression and phosphorylation in motoneurons, and increases the number of in primary afferent projections to motoneurons in mice with post-stroke spasticity." in: PLoS ONE, Vol. 9, Issue 12, pp. e114328, (2015) (PubMed).
: "The developmental switch in GABA polarity is delayed in fragile X mice." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 2, pp. 446-50, (2014) (PubMed).
: "Distribution of neuronal KCC2a and KCC2b isoforms in mouse CNS." in: The Journal of comparative neurology, Vol. 522, Issue 8, pp. 1897-914, (2014) (PubMed).
: "Emergence of motor circuit activity." in: PLoS ONE, Vol. 9, Issue 4, pp. e93836, (2014) (PubMed).
Synonyms and alternative names related to KCC2
solute carrier family 12 member 5 (SLC12A5), solute carrier family 12 member 5 (Slc12a5), solute carrier family 12, member 5 (Slc12a5), Kcc2, KCC2, mKIAA1176Protein level used designations for KCC2
- solute carrier family 12 (potassium/chloride transporter), member 5
- K-Cl cotransporter 2
- electroneutral potassium-chloride cotransporter 2
- furosemide-sensitive K-Cl cotransporter
- neuronal K-Cl cotransporter
- neuronal-specific K-Cl cotransporter
- rKCC2
- solute carrier family 12 member 5
- solute carrier family 12, member 5
- erythroid K-Cl cotransporter 2
- hKCC2
- mKCC2
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