JMY Products
(Junction Mediating and Regulatory Protein, P53 Cofactor (JMY))
Categories
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics.
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Featured JMY Categories
JMY Antibodies
High quality antibodies with extensive validation data.
JMY ELISA Kits
Reliable ELISA kits for a wide range of species.
JMY Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended JMY Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
Cat. No.
ABIN530707
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
Cat. No.
ABIN530706
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (2)
Cat. No.
ABIN7157162
Quantity
100 μg
Datasheet
Datasheet
Recommended JMY ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648309
Quantity
96 tests
Datasheet
Datasheet
Recommended JMY Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123654
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308311
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3093298
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our JMY products
: "A transcription co-factor integrates cell adhesion and motility with the p53 response." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 47, pp. 19872-7, (2009) (PubMed).: "p53-cofactor JMY is a multifunctional actin nucleation factor." in: Nature cell biology, Vol. 11, Issue 4, pp. 451-9, (2009) (PubMed).
: "Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients." in: Genes, chromosomes & cancer, Vol. 47, Issue 8, pp. 680-96, (2008) (PubMed).
: "Mdm2 targets the p53 transcription cofactor JMY for degradation." in: EMBO reports, Vol. 8, Issue 1, pp. 84-90, (2007) (PubMed).
: "A novel cofactor for p300 that regulates the p53 response." in: Molecular cell, Vol. 4, Issue 3, pp. 365-76, (1999) (PubMed).
Synonyms and alternative names related to JMY
junction mediating and regulatory protein, p53 cofactor (JMY), junction mediating and regulatory protein, p53 cofactor (jmy), junction-mediating and regulatory protein (Jmy), WHDC1L3Protein level used designations for JMY
- junction mediating and regulatory protein, p53 cofactor
- junction-mediating and regulatory protein
- junction-mediating and -regulatory protein
- WAS protein homology region 2 domain containing 1-like 3
- p300 transcriptional cofactor JMY
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