ITPK1 Products
(Inositol-Tetrakisphosphate 1-Kinase (ITPK1))
Categories
Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway.
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Featured ITPK1 Categories
ITPK1 Antibodies
High quality antibodies with extensive validation data.
ITPK1 ELISA Kits
Reliable ELISA kits for a wide range of species.
ITPK1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ITPK1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN517270
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, ICC
Validations
- (1)
- (3)
Cat. No.
ABIN2856549
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, RNAi
Validations
- (4)
Cat. No.
ABIN561564
Quantity
100 μg
Datasheet
Datasheet
Recommended ITPK1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN5648267
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Validations
Cat. No.
ABIN1138108
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Chicken
Analytical Method
Validations
Cat. No.
ABIN1138109
Quantity
96 tests
Datasheet
Datasheet
Recommended ITPK1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123440
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308246
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130186
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ITPK1 products
: "MLKL Requires the Inositol Phosphate Code to Execute Necroptosis." in: Molecular cell, Vol. 70, Issue 5, pp. 936-948.e7, (2019) (PubMed).: "Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein." in: Current opinion in cell biology, Vol. 5, Issue 2, pp. 194-200, (1993) (PubMed).
: "The retinoblastoma susceptibility gene encodes a nuclear phosphoprotein associated with DNA binding activity." in: Nature, Vol. 329, Issue 6140, pp. 642-5, (1987) (PubMed).
Synonyms and alternative names related to ITPK1
inositol-tetrakisphosphate 1-kinase (ITPK1), inositol 1,3,4-triphosphate 5/6 kinase (Itpk1), inositol-tetrakisphosphate 1-kinase L homeolog (itpk1.L), inositol-tetrakisphosphate 1-kinase a (itpk1a), inositol-tetrakisphosphate 1-kinase (Itpk1), BC031182, ITRPK1, wu:fj15d08, zgc:56075Protein level used designations for ITPK1
- inositol 1,3,4-triphosphate 5/6 kinase
- inositol 1,3,4-trisphosphate 5/6 kinase
- inositol 1,3,4-trisphosphate 5/6-kinase
- inositol-triphosphate 5/6-kinase
- ins(1,3,4)P(3) 5/6-kinase
- inositol-tetrakisphosphate 1-kinase
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