ITGAL Products
(Integrin alpha-L (ITGAL))
Categories
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured ITGAL Categories
ITGAL Antibodies
High quality antibodies with extensive validation data.
ITGAL ELISA Kits
Reliable ELISA kits for a wide range of species.
ITGAL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ITGAL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, WB, IHC, ELISA
Validations
- (7)
Cat. No.
ABIN7193238
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (7)
Cat. No.
ABIN3015542
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
FACS, IP, IHC
Validations
- (1)
- (4)
Cat. No.
ABIN375486
Quantity
500 μg
Datasheet
Datasheet
Recommended ITGAL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967693
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Cow
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967694
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6960720
Quantity
96 tests
Datasheet
Datasheet
Recommended ITGAL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123469
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
Cat. No.
ABIN2713386
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413577
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ITGAL products
: "Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2." in: Nature communications, Vol. 14, Issue 1, pp. 694, (2023) (PubMed).: "T cell stiffness is enhanced upon formation of immunological synapse." in: eLife, Vol. 10, (2021) (PubMed).
: "The Extracellular Domain of the β2 Integrin β Subunit (CD18) Is Sufficient for Escherichia coli Hemolysin and Aggregatibacter actinomycetemcomitans Leukotoxin Cytotoxic Activity." in: mBio, Vol. 10, Issue 4, (2019) (PubMed).
: "Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling." in: PLoS ONE, Vol. 10, Issue 11, pp. e0143423, (2015) (PubMed).
: "Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy." in: Iranian journal of basic medical sciences, Vol. 17, Issue 11, pp. 874-8, (2015) (PubMed).
: "Endogenous tumor-reactive CD8(+) T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth." in: Oncoimmunology, Vol. 2, Issue 6, pp. e23972, (2013) (PubMed).
: "LFA-1 and ICAM-1 expression induced during melanoma-endothelial cell co-culture favors the transendothelial migration of melanoma cell lines in vitro." in: BMC cancer, Vol. 12, pp. 455, (2012) (PubMed).
: "Inhibition of human Vγ9Vδ2 T-cell antitumoral activity through HLA-G: implications for immunotherapy of cancer." in: Cellular and molecular life sciences : CMLS, (2011) (PubMed).
: "T-lymphocyte-induced, Fas-mediated apoptosis is associated with early keratinocyte differentiation." in: Experimental dermatology, Vol. 19, Issue 4, pp. 372-80, (2010) (PubMed).
: "Neuroprotection in a rabbit model of intraventricular haemorrhage by cyclooxygenase-2, prostanoid receptor-1 or tumour necrosis factor-alpha inhibition." in: Brain : a journal of neurology, Vol. 133, Issue Pt 8, pp. 2264-80, (2010) (PubMed).
Synonyms and alternative names related to ITGAL
integrin subunit alpha L (ITGAL), integrin alpha L (Itgal), (p180), CD11A, Cd11a, CD11a, ITGAL, LFA-1, LFA-1A, LFA1A, Ly-15, Ly-21Protein level used designations for ITGAL
- CD11 antigen-like family member A
- LFA-1 alpha
- LFA-1A
- antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide
- integrin alpha-L
- integrin gene promoter
- leukocyte adhesion glycoprotein LFA-1 alpha chain
- leukocyte function-associated molecule 1 alpha chain
- lymphocyte function-associated antigen 1
- alpha L integrin
- lymphocyte antigen 15
- lymphocyte function associated antigen 1, alpha polypeptide
- integrin LFA1
- lymphocyte function-associated antigen 1, alpha polypeptide
- antigen CD11A
- lymphocyte function-associated antigen 1, alpha
- integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
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