ITCH Products
(Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))
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This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
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Featured ITCH Categories
ITCH Antibodies
High quality antibodies with extensive validation data.
ITCH ELISA Kits
Reliable ELISA kits for a wide range of species.
ITCH Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ITCH Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, WB, IF, FACS
Validations
- (5)
Cat. No.
ABIN334426
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (3)
Cat. No.
ABIN7268032
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (2)
Cat. No.
ABIN7180034
Quantity
100 μL
Datasheet
Datasheet
Recommended ITCH ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1381250
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951536
Quantity
96 tests
Datasheet
Datasheet
Recommended ITCH Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123643
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308153
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7504453
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ITCH products
: "Novel signatures of cancer-associated fibroblasts." in: International journal of cancer, Vol. 133, Issue 2, pp. 286-93, (2013) (PubMed).: "Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination." in: Nature cell biology, Vol. 8, Issue 12, pp. 1415-23, (2006) (PubMed).
: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).
: "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45267-75, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice." in: Nature genetics, Vol. 18, Issue 2, pp. 143-6, (1998) (PubMed).
Synonyms and alternative names related to ITCH
itchy E3 ubiquitin protein ligase (ITCH), itchy, E3 ubiquitin protein ligase (Itch), itchy E3 ubiquitin protein ligase (Itch), 6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1Protein level used designations for ITCH
- E3 ubiquitin-protein ligase Itchy homolog
- NFE2-associated polypeptide 1
- atrophin-1 interacting protein 4
- dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
- itchy E3 ubiquitin protein ligase homolog
- E3 ubiquitin-protein ligase Itchy
- itch E3 ubiquitin ligase
- itchy homolog E3 ubiquitin protein ligase
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