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ITCH Products

(Itchy E3 Ubiquitin Protein Ligase Homolog (ITCH))

Categories

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].

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Featured ITCH Categories

ITCH Antibodies

High quality antibodies with extensive validation data.

ITCH ELISA Kits

Reliable ELISA kits for a wide range of species.

ITCH Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ITCH Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IF, FACS
Validations
  • (5)
Cat. No. ABIN334426
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (3)
Cat. No. ABIN7268032
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, WB
Validations
  • (2)
Cat. No. ABIN7180034
Quantity 100 μL
Datasheet Datasheet

Recommended ITCH ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1381250
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6951536
Quantity 96 tests
Datasheet Datasheet

Recommended ITCH Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123643
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308153
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7504453
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our ITCH products

Bozóky, Savchenko, Csermely, Korcsmáros, Dúl, Pontén, Székely, Klein: "Novel signatures of cancer-associated fibroblasts." in: International journal of cancer, Vol. 133, Issue 2, pp. 286-93, (2013) (PubMed).

Di Marcotullio, Ferretti, Greco, De Smaele, Po, Sico, Alimandi, Giannini, Maroder, Screpanti, Gulino: "Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination." in: Nature cell biology, Vol. 8, Issue 12, pp. 1415-23, (2006) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Courbard, Fiore, Adélaïde, Borg, Birnbaum, Ollendorff: "Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 45267-75, (2002) (PubMed).

Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

Perry, Hustad, Swing, OSullivan, Jenkins, Copeland: "The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice." in: Nature genetics, Vol. 18, Issue 2, pp. 143-6, (1998) (PubMed).

Synonyms and alternative names related to ITCH

itchy E3 ubiquitin protein ligase (ITCH), itchy, E3 ubiquitin protein ligase (Itch), itchy E3 ubiquitin protein ligase (Itch), 6720481N21Rik, 8030492O04Rik, A130065M08, AIF4, AIP4, C230047C07Rik, dJ468O1.1, NAPP1

Protein level used designations for ITCH

  • E3 ubiquitin-protein ligase Itchy homolog
  • NFE2-associated polypeptide 1
  • atrophin-1 interacting protein 4
  • dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4))
  • itchy E3 ubiquitin protein ligase homolog
  • E3 ubiquitin-protein ligase Itchy
  • itch E3 ubiquitin ligase
  • itchy homolog E3 ubiquitin protein ligase
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