ISCU Products
(Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (ISCU))
Categories
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria. [provided by RefSeq, Jul 2008].
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Featured ISCU Categories
ISCU Antibodies
High quality antibodies with extensive validation data.
ISCU Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ISCU Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (4)
Cat. No.
ABIN565100
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6262671
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (5)
- (2)
Cat. No.
ABIN1881467
Quantity
400 μL
Datasheet
Datasheet
Recommended ISCU ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229179
Quantity
96 tests
Datasheet
Datasheet
Recommended ISCU Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308129
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7288777
Quantity
200 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN6386664
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our ISCU products
: "Metabolic adaptation to chronic hypoxia in cardiac mitochondria." in: Basic research in cardiology, Vol. 107, Issue 3, pp. 268, (2012) (PubMed).: "Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 12, pp. 4362-8, (2010) (PubMed).
: "MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2." in: Cell metabolism, Vol. 10, Issue 4, pp. 273-84, (2009) (PubMed).
: "Clinical manifestation and a new ISCU mutation in iron-sulphur cluster deficiency myopathy." in: Brain : a journal of neurology, Vol. 132, Issue Pt 8, pp. 2170-9, (2009) (PubMed).
: "Mapping iron binding sites on human frataxin: implications for cluster assembly on the ISU Fe-S cluster scaffold protein." in: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Vol. 13, Issue 5, pp. 825-36, (2008) (PubMed).
: "Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance." in: American journal of human genetics, Vol. 82, Issue 3, pp. 652-60, (2008) (PubMed).
Synonyms and alternative names related to ISCU
iron-sulfur cluster assembly enzyme ISCU, mitochondrial (LOC409130), iron-sulfur cluster assembly enzyme (ISCU), iron-sulfur cluster assembly enzyme a (iscua), iron-sulfur cluster assembly enzyme (Iscu), 2310020H20Rik, AA407971, HML, hnifU, ISU2, NIFU, Nifu, nifun, NIFUN, Nifun, RGD1309562, si:ch211-191d15.3, zC191D15.3Protein level used designations for ISCU
- iron-sulfur cluster assembly enzyme ISCU, mitochondrial
- iron-sulfur cluster scaffold homolog (E. coli)
- iron-sulfur cluster assembly enzyme
- IscU iron-sulfur cluster scaffold homolog (E. coli)
- NifU-like N-terminal domain containing
- zC191D15.3 (novel protein with leucine-rich repeat domains)
- IscU iron-sulfur cluster scaffold homolog
- iron-sulfur cluster scaffold homolog
- nifU-like N-terminal domain-containing protein
- nifU-like protein
- ISCU2
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