IRGM Products
(Immunity-Related GTPase Family, M (IRGM))
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This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010].
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Featured IRGM Categories
IRGM Antibodies
High quality antibodies with extensive validation data.
IRGM Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IRGM Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN5066473
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN5066477
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN5066465
Quantity
100 μg
Datasheet
Datasheet
Recommended IRGM Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN1098712
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1308106
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130169
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IRGM products
: "Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. ..." in: Nature genetics, Vol. 40, Issue 6, pp. 710-2, (2008) (PubMed).: "Genome-wide association scanning highlights two autophagy genes, ATG16L1 and IRGM, as being significantly associated with Crohn's disease." in: Autophagy, Vol. 3, Issue 6, pp. 649-51, (2007) (PubMed).
: "Human IRGM induces autophagy to eliminate intracellular mycobacteria." in: Science (New York, N.Y.), Vol. 313, Issue 5792, pp. 1438-41, (2006) (PubMed).
: "Autophagy as a cell death and tumor suppressor mechanism." in: Oncogene, Vol. 23, Issue 16, pp. 2891-906, (2004) (PubMed).
Synonyms and alternative names related to IRGM
immunity-related GTPase family M member 1 (Irgm1), immunity-related GTPase M (Irgm), immunity related GTPase M (IRGM), immunity-related GTPase family M protein (LOC481473), Ifi1, IFI1, Iigp3, Iipg3, Irgm, IRGM1, LRG-47, LRG47Protein level used designations for IRGM
- LPS-stimulated RAW 264.7 macrophage protein 47
- immunity-related GTPase family M protein 1
- immunity-related GTPase family, M
- interferon inducible protein 1
- interferon-inducible GTPase 3
- interferon-inducible protein 1
- immunity-related GTPase family M protein
- LPS-stimulated RAW 264.7 macrophage protein 47 homolog
- LRG-47-like protein
- immunity-related GTPase family, M1
- immunity-related GTPase M
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