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IRF8 Products

(Interferon Regulatory Factor 8 (IRF8))
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008].

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Featured IRF8 Categories

IRF8 Antibodies

High quality antibodies with extensive validation data.

IRF8 ELISA Kits

Reliable ELISA kits for a wide range of species.

IRF8 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IRF8 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
Cat. No. ABIN7444418
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (5)
Cat. No. ABIN2792611
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7444517
Quantity 100 μL
Datasheet Datasheet

Recommended IRF8 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967758
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1138463
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1138462
Quantity 96 tests
Datasheet Datasheet

Recommended IRF8 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308098
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308100
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418326
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IRF8 products

Yu, Liu, Zhu, Zhu, Lv, Wang, Wang, Peng: "The Expression of Interferon Regulatory Factor 8 in Human Periapical Lesions." in: Journal of endodontics, Vol. 44, Issue 8, pp. 1276-1282, (2019) (PubMed).

Xiang, Wang, Guo, Lu, Lei, Jiang, Zhang, Liu, Zhou, Zhang, Li: "Interferon regulatory factor 8 protects against cerebral ischaemic-reperfusion injury." in: Journal of neurochemistry, Vol. 129, Issue 6, pp. 988-1001, (2014) (PubMed).

Conzelmann, Wagner, Hildebrandt, Rodionova, Hess, Zota, Giese, Falk, Ho, Dreger, Hecker, Luft: "IFN-? activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production." in: Biochemical pharmacology, Vol. 80, Issue 12, pp. 2074-86, (2010) (PubMed).

Ye, Wang, Wang, Wang, Song, Hou, Zhou, Li, Ho: "CD56+ T cells inhibit hepatitis C virus replication in human hepatocytes." in: Hepatology (Baltimore, Md.), Vol. 49, Issue 3, pp. 753-62, (2009) (PubMed).

Tsujimura, Tamura, Kong, Nishiyama, Ishii, Klinman, Ozato: "Toll-like receptor 9 signaling activates NF-kappaB through IFN regulatory factor-8/IFN consensus sequence binding protein in dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 11, pp. 6820-7, (2004) (PubMed).

Heiser, Labi, Erlacher, Villunger: "The Bcl-2 protein family and its role in the development of neoplastic disease." in: Experimental gerontology, Vol. 39, Issue 8, pp. 1125-35, (2004) (PubMed).

Malmgaard: "Induction and regulation of IFNs during viral infections." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 24, Issue 8, pp. 439-54, (2004) (PubMed).

Cory, Huang, Adams: "The Bcl-2 family: roles in cell survival and oncogenesis." in: Oncogene, Vol. 22, Issue 53, pp. 8590-607, (2003) (PubMed).

Lockshin, Osborne, Zakeri: "Cell death in the third millennium." in: Cell death and differentiation, Vol. 7, Issue 1, pp. 2-7, (2000) (PubMed).

González-García, Pérez-Ballestero, Ding, Duan, Boise, Thompson, Núñez: "bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria." in: Development (Cambridge, England), Vol. 120, Issue 10, pp. 3033-42, (1995) (PubMed).

Synonyms and alternative names related to IRF8

interferon regulatory factor 8 (irf8), interferon regulatory factor 8 (IRF8), interferon regulatory factor 8 L homeolog (irf8.L), interferon regulatory factor 8 (Irf8), AI893568, DKFZp469B0320, H-ICSBP, ICSBP, ICSBP1, icsbp1, Icsbp1, IRF-8, IRF8, MGC140338, Myls, zgc:92252

Protein level used designations for IRF8

  • DKEYP-77B5.1
  • interferon regulatory factor 8
  • interferon regulatory factor 8-like
  • interferon consensus sequence binding protein 1
  • interferon consensus sequence-binding protein
  • transcription factor ICSBP
  • IRF-8
  • interferon consensus sequence binding protein
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