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IRF6 Products

(Interferon Regulatory Factor 6 (IRF6))

Categories

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011].

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Featured IRF6 Categories

IRF6 Antibodies

High quality antibodies with extensive validation data.

IRF6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IRF6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Human, Rat
Application WB, IHC, IF, FACS, IHC (p)
Validations
  • (14)
Cat. No. ABIN1498901
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (5)
Cat. No. ABIN7101507
Quantity 20 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (4)
Cat. No. ABIN184730
Quantity 100 μg
Datasheet Datasheet

Recommended IRF6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967757
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6205230
Quantity 96 tests
Datasheet Datasheet

Recommended IRF6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308096
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308094
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7413994
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our IRF6 products

Li, Ying, Huang, Brehm, Morin, Vella, Zhou: "IRF6 Regulates Alternative Activation by Suppressing PPARγ in Male Murine Macrophages." in: Endocrinology, Vol. 158, Issue 9, pp. 2837-2847, (2017) (PubMed).

Hu, Liu, Li, Ozturk, Gurumurthy, Romano, Sinha, Nawshad: "TGFβ3 regulates periderm removal through ΔNp63 in the developing palate." in: Journal of cellular physiology, Vol. 230, Issue 6, pp. 1212-25, (2015) (PubMed).

Kwa, Nguyen, Huynh, Ramnath, De Nardo, Lam, Reynolds, Hamilton, Sweet, Scholz: "Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells." in: The Journal of biological chemistry, Vol. 289, Issue 28, pp. 19758-68, (2014) (PubMed).

Iwata, Suzuki, Pelikan, Ho, Sanchez-Lara, Urata, Dixon, Chai: "Smad4-Irf6 genetic interaction and TGF?-mediated IRF6 signaling cascade are crucial for palatal fusion in mice." in: Development (Cambridge, England), Vol. 140, Issue 6, pp. 1220-30, (2013) (PubMed).

Botti, Spallone, Moretti, Marinari, Pinetti, Galanti, De Meo, De Nicola, Ganci, Castrignanò, Pesole, Chimenti, Guerrini, Fanciulli, Blandino, Karin, Costanzo: "Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 33, pp. 13710-5, (2011) (PubMed).

Moretti, Marinari, Lo Iacono, Botti, Giunta, Spallone, Garaffo, Vernersson-Lindahl, Merlo, Mills, Ballarò, Alemà, Chimenti, Guerrini, Costanzo: "A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias." in: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1570-7, (2010) (PubMed).

Bailey, Abbott, Margaryan, Khalkhali-Ellis, Hendrix: "Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner." in: Molecular and cellular biology, Vol. 28, Issue 7, pp. 2235-43, (2008) (PubMed).

Vieira, Cooper, Marazita, Orioli, Castilla: "Interferon regulatory factor 6 (IRF6) is associated with oral-facial cleft in individuals that originate in South America." in: American journal of medical genetics. Part A, Vol. 143A, Issue 17, pp. 2075-8, (2007) (PubMed).

Jakobsen, Ullmann, Kjaer, Knudsen, Tommerup, Eiberg: "Suggestive linkage to a neighboring region of IRF6 in a cleft lip and palate multiplex family." in: American journal of medical genetics. Part A, Vol. 143A, Issue 22, pp. 2716-21, (2007) (PubMed).

Kondo, Schutte, Richardson, Bjork, Knight, Watanabe, Howard, de Lima, Daack-Hirsch, Sander, McDonald-McGinn, Zackai, Lammer, Aylsworth, Ardinger, Lidral, Pober, Moreno, Arcos-Burgos, Valencia et al.: "Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. ..." in: Nature genetics, Vol. 32, Issue 2, pp. 285-9, (2002) (PubMed).

Synonyms and alternative names related to IRF6

interferon regulatory factor 6 (IRF6), interferon regulatory factor 6 (irf6), interferon regulatory factor 6 S homeolog (irf6.S), interferon regulatory factor 6 (Irf6), AI876454, DKFZp469E012, E230028I05Rik, IRF6, lps, LPS, mirf6, ofc6, OFC6, pit, PIT, pps, PPS, PPS1, vws, VWS, VWS1, xIRF-6, zgc:63500

Protein level used designations for IRF6

  • interferon regulatory factor 6
  • interferon regulatory factor 6-like
  • IRF-6
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