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IRF3 Products

(Interferon Regulatory Factor 3 (IRF3))

Categories

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

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Featured IRF3 Categories

IRF3 Antibodies

High quality antibodies with extensive validation data.

IRF3 ELISA Kits

Reliable ELISA kits for a wide range of species.

IRF3 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IRF3 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Monkey, Mouse, Rat
Application WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro)
Validations
  • (4)
  • (5)
Cat. No. ABIN742688
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF, ChIP
Validations
  • (1)
  • (5)
Cat. No. ABIN6142528
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IP
Validations
  • (5)
Cat. No. ABIN517226
Quantity 100 μg
Datasheet Datasheet

Recommended IRF3 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956910
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN5691022
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967754
Quantity 96 tests
Datasheet Datasheet

Recommended IRF3 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (4)
  • (1)
Cat. No. ABIN1308082
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123496
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308084
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our IRF3 products

Sprokholt, Kaptein, van Hamme, Overmars, Gringhuis, Geijtenbeek: "RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production." in: PLoS pathogens, Vol. 13, Issue 11, pp. e1006738, (2018) (PubMed).

Wang, Sun, Yi, Zhang, Lin, Sun, Chen, Jin: "AGO2 Negatively Regulates Type I Interferon Signaling Pathway by Competition Binding IRF3 with CBP/p300." in: Frontiers in cellular and infection microbiology, Vol. 7, pp. 195, (2018) (PubMed).

Ando, Matsumoto, Taguchi, Kobayashi: "Poly (I:C) impairs NO donor-induced relaxation by overexposure to NO via the NF-kappa B/iNOS pathway in rat superior mesenteric arteries." in: Free radical biology & medicine, Vol. 112, pp. 553-566, (2017) (PubMed).

Yu, Wang, He, Wang, Gao, Ren, Shi et al.: "Curcumin exerts anti-inflammatory and antioxidative properties in 1-methyl-4-phenylpyridinium ion (MPP(+))-stimulated mesencephalic astrocytes by interference with TLR4 and downstream signaling ..." in: Cell stress & chaperones, Vol. 21, Issue 4, pp. 697-705, (2017) (PubMed).

Zhu, Wang, Pei, Wang, Wu, Qiu, Zhang, Lv, Li, Zhang: "Neddylation controls basal MKK7 kinase activity in breast cancer cells." in: Oncogene, Vol. 35, Issue 20, pp. 2624-33, (2017) (PubMed).

Ye, Chen, Li, Zhao, He, Zohaib, Song, Deng, Zhang, Chen, Cao: "Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB." in: Journal of virology, Vol. 91, Issue 8, (2017) (PubMed).

Qian, Fan, Liu, Wu, Zhang, Cui, Zhou, Hu, Wei, Chen, Li, Qian: "Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage." in: Journal of virology, Vol. 91, Issue 16, (2017) (PubMed).

Fan, Li, Zhu, Sui, Chen, Deng, Sui, Wang: "NF-κB is involved in the LPS-mediated proliferation and apoptosis of MAC-T epithelial cells as part of the subacute ruminal acidosis response in cows." in: Biotechnology letters, Vol. 38, Issue 11, pp. 1839-1849, (2016) (PubMed).

Pourcelot, Zemirli, Silva Da Costa, Loyant, Garcin, Vitour, Munitic, Vazquez, Arnoult: "The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing." in: BMC biology, Vol. 14, pp. 69, (2016) (PubMed).

Zhang, Wang, Zhong, Luo, Shang, Liu, Chen, Fang, Xiao: "Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms." in: Scientific reports, Vol. 5, pp. 11220, (2016) (PubMed).

Synonyms and alternative names related to IRF3

interferon regulatory factor 3 (irf3), interferon regulatory factor 3 (IRF3), interferon regulatory factor 3 (irf-3), interferon regulatory factor 3 (Irf3), interferon regulatory factor 7 (IRF7), C920001K05Rik, IRF-3, irf3, IRF3

Protein level used designations for IRF3

  • interferon regulatory factor 3
  • interferon regulatory factor 3-like
  • IRF-3
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