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UNC-2170 HCl

Inh 1648707-58-7 3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Catalog No. ABIN7233306
  • Application
    Inhibition (Inh)
    Purpose
    Methyl-lysine binding protein inhibitor
    Characteristics
    UNC-2170, identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.
    Purity
    >98 %
    Chemical Name
    3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
    Formula
    C14H21BrN2O • HCl
    Solubility
    Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Precaution of Use
    GHS – Classification
    Not a hazardous substance
    Storage
    -20 °C
  • Background
    Epigenetics,DNA,Chromatin,DNA repair
    Molecular Weight
    349.7
    CAS-No
    1648707-58-7
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