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UNC1999

Inh 1431612-23-5 N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
Catalog No. ABIN7233305
  • Application
    Inhibition (Inh)
    Purpose
    Methyltransferase inhibitor
    Characteristics
    UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively). Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells.
    Purity
    >98 %
    Chemical Name
    N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide
    Formula
    C33H43N7O2
    Solubility
    Soluble in DMSO (up to 10 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Epigenetics,Proliferation,Protein methyltransferase,Cancer,Posttranslational modification,Chromatin
    Molecular Weight
    569.74
    CAS-No
    1431612-23-5
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