Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

UNC-0379

Inh 1620401-82-2 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
Catalog No. ABIN7233304
  • Application
    Inhibition (Inh)
    Purpose
    SETD8 inhibitor
    Characteristics
    UNC0379 is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases. IC50's = 7.3 μM in a radioactive methyl transfer assay and 9.0 μM in an MCE assay. UNC0379 treatment of SY5Y and NGP neuroblastoma cell lines lead to activation of p53 and decreased tumor growth in an ex-vivo tumorigenicity assay.
    Purity
    >98 %
    Chemical Name
    6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)-pentyl)quinazolin-4-amine
    Formula
    C23H35N5O2
    Solubility
    Soluble in DMSO (up to 30 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Proliferation,Epigenetics,p53,Protein methyltransferase,Neuroscience,Cancer,Posttranslational modification,Chromatin
    Molecular Weight
    413.56
    CAS-No
    1620401-82-2
You are here:
Support