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SP2509

Inh 1423715-09-6 (E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide
Catalog No. ABIN7233293
  • Application
    Inhibition (Inh)
    Purpose
    LSD1 Inhibitor
    Characteristics
    SP2509 is a potent (IC50 = 13 nM), reversible, non-competitive inhibitor of histone demethylase LSD1 (KDM1A), selective over the closely related flavin enzymes MAO A & B, lactate dehydrogenase, several CYPs, or hERG. It inhibits growth and induces differentiation of cancer stem cells, e.g. AML progenitor cells, and promotes autophagy in neuroblastoma cells. It also causes cancer cell death independent if LSD1, possibly through downregulation of Bcl-2 and Mcl-1. Also inhibits HSV-1 infection by blocking viral DNA replication and gene expression.
    Purity
    >98 %
    Chemical Name
    (E)-N'-(1-(5-Chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide
    Formula
    C19H20ClN3O5S
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Bcl,Epigenetics,Posttranslational modification,Protein demethylase,Cell death,Cancer Stem Cells,Infectious disease,Cancer,Autophagy,Chromatin
    Molecular Weight
    437.90
    CAS-No
    1423715-09-6
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