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Sirtinol

Inh Cell-permeable 410536-97-9 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
Catalog No. ABIN7233291
  • Application
    Inhibition (Inh)
    Purpose
    SIRT inhibitor
    Characteristics
    Inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60μM), human SIRT2 (IC50=58μM), and yeast Sir2 (IC50=48μM) with no inhibition of human HDAC1. Active in vivo and in purified enzyme studies. Cell permeable.
    Purity
    >98 %
    Chemical Name
    2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]-N-(1-phenylethyl)benzamide
    Formula
    C26H22N2O2
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 30 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Precaution of Use
    GHS – Classification
    Skin corrosion/irritation (Category 2), H315
    Serious eye damage/eye irritation (Category 2A), H319
    Specific target organ toxicity-single exposure (Category 3): Respiratory system, H335
    Storage
    -20 °C
  • Background
    Epigenetics,Protein deacetylase,Stem cells,Posttranslational modification,Chromatin
    Molecular Weight
    394.48
    CAS-No
    410536-97-9
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