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Scriptaid

Inh 287383-59-9 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Catalog No. ABIN7233287
  • Application
    Inhibition (Inh)
    Purpose
    HDAC inhibitor
    Characteristics
    Inhibits histone deacetylases (HDAC) 1 and 3 (IC50~0.6 μM) and HDAC8 (IC50~1 μM) and is less toxic compared to trichostatin A. Induces cell cycle arrest and epigenetic changes in colon cancer cells. Together with DRB-inhibition of RNA synthesis, scriptaid enhances gene reprogramming in somatic cell nuclear transfer (SCNT) embryos. Increases exercise endurance in mice.
    Purity
    >98 %
    Chemical Name
    6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
    Formula
    C18H18N2O4
    Solubility
    Soluble in DMSO (up to 4 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    RT
  • Background
    Scriptide, GCK1026,Proliferation,Epigenetics,Cell cycle,Protein deacetylase,Stem cells,Cancer,Posttranslational modification,Chromatin
    Molecular Weight
    326.35
    CAS-No
    287383-59-9
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