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Inh 1105698-15-4 N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
Catalog No. ABIN7233285
  • Application
    Inhibition (Inh)
    Purpose
    SIRT1&2 inhibitor
    Characteristics
    SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours. Displays protective effect in nematodes expressing muscular dystrophy protein. Promotes neuronal apoptosis confirming the protective effect of SIRT1.
    Purity
    >98 %
    Chemical Name
    N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
    Formula
    C26H22N2O2
    Solubility
    Soluble in DMSO (up to 40 mg/ml), in DMF (up to 30 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Precaution of Use
    GHS – Classification
    Not a hazardous substance
    Storage
    -20 °C
  • Background
    Epigenetics,Posttranslational modification,Protein deacetylase,Neuroscience,Cell death,Apoptosis inducer,Chromatin
    Molecular Weight
    394.47
    CAS-No
    1105698-15-4
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