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Romidepsin (FK-228)

Inh 128517-07-7
Catalog No. ABIN7233282
  • Application
    Inhibition (Inh)
    Purpose
    HDAC inhibitor
    Characteristics
    A potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively. Induces apoptosis in a variety of cell lines and displays antitumor activity in mouse models. Recently approved for clinical use in T-cell lymphoma.
    Purity
    >98 %
    Formula
    C24H36N4O6S2
    Solubility
    Soluble in DMSO (up to 10 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    FR901228, Depsipeptide,Epigenetics,Posttranslational modification,Protein deacetylase,Cell death,Cancer,Apoptosis inducer,Chromatin
    Molecular Weight
    540.7
    CAS-No
    128517-07-7
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