RGFP966
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- Application
- Inhibition (Inh)
- Purpose
- Selective HDAC3 inhibitor
- Characteristics
- RGFP966 is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited at 15μM). It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.
- Purity
- >98 %
- Chemical Name
- (2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
- Formula
- C21H19FN4O
- Solubility
- Soluble in DMSO (up to 20 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
CI-994Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Tranylcypromine hemisulfate (±)Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Tenovin-1Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
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- Restrictions
- For Research Use only
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- Format
- Powder
- Storage
- -20 °C
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- Background
- Epigenetics,Protein deacetylase,Neuroscience,Neurodegeneration,Addiction,Posttranslational modification,Chromatin
- Molecular Weight
- 362.40
- CAS-No
- 1357389-11-7
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