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RGFP966

Inh 1357389-11-7 (2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
Catalog No. ABIN7233281
  • Application
    Inhibition (Inh)
    Purpose
    Selective HDAC3 inhibitor
    Characteristics
    RGFP966 is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited at 15μM). It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.
    Purity
    >98 %
    Chemical Name
    (2E)-N-(2-Amino-4-fluorophenyl)-3-[(2E)-1-(3-phenyl-2-propen-1-yl)-1H-pyrazol-4-yl]-2-propenamide
    Formula
    C21H19FN4O
    Solubility
    Soluble in DMSO (up to 20 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Epigenetics,Protein deacetylase,Neuroscience,Neurodegeneration,Addiction,Posttranslational modification,Chromatin
    Molecular Weight
    362.40
    CAS-No
    1357389-11-7
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